Recent development of vinylogous Mukaiyama aldol reactions

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35 Citations (Scopus)


The vinylogous Mukaiyama aldol reaction (VMAR) is a powerful tool of polyketide synthesis, which constructs a large size structure by simultaneous introduction of the stereogenic center(s) and the α,β-unsaturated carbonyl group. A variety of stereocontrolled VMARs have been developed and applied to natural product synthesis. This review is focused on recent development of the vinylogous Mukaiyama aldol reaction using s-trans silyl dienolates.

Original languageEnglish
Pages (from-to)77-88
Number of pages12
JournalTetrahedron Letters
Issue number2
Publication statusPublished - 2018 Jan 10


  • Natural product synthesis
  • Polyketide
  • Silyl dienolate
  • Stereoselective synthesis
  • Vinylogous Mukaiyama aldol reaction

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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