Abstract
The vinylogous Mukaiyama aldol reaction (VMAR) is a powerful tool of polyketide synthesis, which constructs a large size structure by simultaneous introduction of the stereogenic center(s) and the α,β-unsaturated carbonyl group. A variety of stereocontrolled VMARs have been developed and applied to natural product synthesis. This review is focused on recent development of the vinylogous Mukaiyama aldol reaction using s-trans silyl dienolates.
Original language | English |
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Pages (from-to) | 77-88 |
Number of pages | 12 |
Journal | Tetrahedron Letters |
Volume | 59 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2018 Jan 10 |
Keywords
- Natural product synthesis
- Polyketide
- Silyl dienolate
- Stereoselective synthesis
- Vinylogous Mukaiyama aldol reaction
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry