Recent progress in nickel-catalyzed biaryl coupling

Junichiro Yamaguchi*, Kei Muto, Kenichiro Itami

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

461 Citations (Scopus)


Nickel catalysis for biaryl coupling reactions has received significant attention as a less expensive and less toxic alternative to "standard" palladium catalysis. Here we describe recent developments in nickel-catalyzed biaryl coupling methodology, along with mechanistic studies and applications. In particular we focus on nickel-catalyzed coupling reactions in which "unreactive" bonds such as C-H, C-O, and C-C bonds are converted into biaryl moieties. Biaryl coupling through nickel catalysis has been known for a few decades. The topic has recently resurfaced in synthetic chemistry, however, thanks to its use of ideal coupling partners such as simple arenes (Ar-H) and phenol derivatives (Ar-OR). In this microreview, recent achievements in nickel-catalyzed biaryl coupling are summarized.

Original languageEnglish
Pages (from-to)19-30
Number of pages12
JournalEuropean Journal of Organic Chemistry
Issue number1
Publication statusPublished - 2013 Jan 1
Externally publishedYes


  • Arylation
  • Biaryls
  • C-C coupling
  • C-H functionalization
  • Homogeneous catalysis
  • Nickel

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry


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