Reconstruction of tissue and gene expression

Akiyoshi Taniguchi*

*Corresponding author for this work

Research output: Contribution to conferencePaperpeer-review


Cell-cell communication between multiple cell populations is believed to be important for the activation of many cellular functions. It has previously been reported that rat hepatocytes in a double layer co-culture system with human endothelial cells were able to maintain albumin expression for a prolonged period of time. This result suggests that essential functions of hepatocytes were maintained via communication with endothelial cells in this co-culture system. In order to analyze the hepatocyte gene expression profile of double-layered co-culture, we try to isolate cDNAs, which increase in this co-culture system, from a subtractive library constructed by suppression subtractive hybridization (SSH). The results indicate that the many hepatocyte functions are increased by layered with HUVEC.

Original languageEnglish
Number of pages2
Publication statusPublished - 2006 Dec 1
Externally publishedYes
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: 2006 Sept 202006 Sept 22


Other55th Society of Polymer Science Japan Symposium on Macromolecules


  • Cell sheet
  • Co-culture
  • Gene expression
  • Re-construction of liver

ASJC Scopus subject areas

  • Engineering(all)


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