Reduction of serum TARC levels in atopic dermatitis by topical anti-inflammatory treatments

Yumi Yasukochi; Takeshi Nakahara; Takeru Abe; Makiko Kido-Nakahara; Futoshi Kohda; Satoshi Takeuchi; Akihito Hagihara; Masutaka Furue

doi:10.12932/AP0419.32.3.2014

Reduction of serum TARC levels in atopic dermatitis by topical anti-inflammatory treatments

Yumi Yasukochi^*, Takeshi Nakahara, Takeru Abe, Makiko Kido-Nakahara, Futoshi Kohda, Satoshi Takeuchi, Akihito Hagihara, Masutaka Furue

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Background: Serum thymus and activation-regulated chemokine (TARC) levels are associated with the disease activity of patients with atopic dermatitis (AD) and sensitively reflect short-term changes in skin conditions. The main treatment for AD is topical agent application.

Objective: This study investigated the relationship between serum TARC levels and the dosage of topical agents, including corticosteroids and/or tacrolimus, in patients with AD.

Methods: The serum TARC levels of 56 AD patients and the amounts of topical agents prescribed to them were investigated retrospectively. The weekly reduction in serum TARC levels and weekly dosage of topical agents among AD patients were compared and their associations were evaluated.

Results: The dosage of topical agents was closely related to serum TARC levels. One gram of strong rank steroid or the equivalent amount of steroid/tacrolimus is required to reduce serum TARC levels by 9.94 pg/mL weekly in moderate to severe AD patients. Higher initial TARC levels require more topical agent, which results in a more rapid decrease in TARC levels. The serum TARC levels and eosinophil numbers in peripheral blood are significantly correlated.

Conclusion: Serum TARC level improvement and topical agent dosage are strongly correlated. TARC and eosinophil numbers are significantly correlated, but the wider range of TARC levels seems to be clinically more useful for monitoring AD severity. The serum TARC level is a very sensitive biomarker for monitoring the severity and treatment response in AD.

Original language	English
Pages (from-to)	240-245
Number of pages	6
Journal	Asian Pacific Journal of Allergy and Immunology
Volume	32
Issue number	3
DOIs	https://doi.org/10.12932/AP0419.32.3.2014
Publication status	Published - 2014 Sept 1

Keywords

Atopic dermatitis
Serum thymus and activation-regulated chemokine (TARC) levels
Topical corticosteroids
Topical tacrolimus
Total equivalent amounts (TEA)

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Medicine(all)

Access to Document

10.12932/AP0419.32.3.2014

Cite this

@article{f994e327bc6e47149e084f450695ead6,

title = "Reduction of serum TARC levels in atopic dermatitis by topical anti-inflammatory treatments",

abstract = "Background: Serum thymus and activation-regulated chemokine (TARC) levels are associated with the disease activity of patients with atopic dermatitis (AD) and sensitively reflect short-term changes in skin conditions. The main treatment for AD is topical agent application.Objective: This study investigated the relationship between serum TARC levels and the dosage of topical agents, including corticosteroids and/or tacrolimus, in patients with AD.Methods: The serum TARC levels of 56 AD patients and the amounts of topical agents prescribed to them were investigated retrospectively. The weekly reduction in serum TARC levels and weekly dosage of topical agents among AD patients were compared and their associations were evaluated.Results: The dosage of topical agents was closely related to serum TARC levels. One gram of strong rank steroid or the equivalent amount of steroid/tacrolimus is required to reduce serum TARC levels by 9.94 pg/mL weekly in moderate to severe AD patients. Higher initial TARC levels require more topical agent, which results in a more rapid decrease in TARC levels. The serum TARC levels and eosinophil numbers in peripheral blood are significantly correlated.Conclusion: Serum TARC level improvement and topical agent dosage are strongly correlated. TARC and eosinophil numbers are significantly correlated, but the wider range of TARC levels seems to be clinically more useful for monitoring AD severity. The serum TARC level is a very sensitive biomarker for monitoring the severity and treatment response in AD.",

keywords = "Atopic dermatitis, Serum thymus and activation-regulated chemokine (TARC) levels, Topical corticosteroids, Topical tacrolimus, Total equivalent amounts (TEA)",

author = "Yumi Yasukochi and Takeshi Nakahara and Takeru Abe and Makiko Kido-Nakahara and Futoshi Kohda and Satoshi Takeuchi and Akihito Hagihara and Masutaka Furue",

year = "2014",

month = sep,

day = "1",

doi = "10.12932/AP0419.32.3.2014",

language = "English",

volume = "32",

pages = "240--245",

journal = "Asian Pacific Journal of Allergy and Immunology",

issn = "0125-877X",

publisher = "The Allergy and Immunology Society of Thailand",

number = "3",

}

TY - JOUR

T1 - Reduction of serum TARC levels in atopic dermatitis by topical anti-inflammatory treatments

AU - Yasukochi, Yumi

AU - Nakahara, Takeshi

AU - Abe, Takeru

AU - Kido-Nakahara, Makiko

AU - Kohda, Futoshi

AU - Takeuchi, Satoshi

AU - Hagihara, Akihito

AU - Furue, Masutaka

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Background: Serum thymus and activation-regulated chemokine (TARC) levels are associated with the disease activity of patients with atopic dermatitis (AD) and sensitively reflect short-term changes in skin conditions. The main treatment for AD is topical agent application.Objective: This study investigated the relationship between serum TARC levels and the dosage of topical agents, including corticosteroids and/or tacrolimus, in patients with AD.Methods: The serum TARC levels of 56 AD patients and the amounts of topical agents prescribed to them were investigated retrospectively. The weekly reduction in serum TARC levels and weekly dosage of topical agents among AD patients were compared and their associations were evaluated.Results: The dosage of topical agents was closely related to serum TARC levels. One gram of strong rank steroid or the equivalent amount of steroid/tacrolimus is required to reduce serum TARC levels by 9.94 pg/mL weekly in moderate to severe AD patients. Higher initial TARC levels require more topical agent, which results in a more rapid decrease in TARC levels. The serum TARC levels and eosinophil numbers in peripheral blood are significantly correlated.Conclusion: Serum TARC level improvement and topical agent dosage are strongly correlated. TARC and eosinophil numbers are significantly correlated, but the wider range of TARC levels seems to be clinically more useful for monitoring AD severity. The serum TARC level is a very sensitive biomarker for monitoring the severity and treatment response in AD.

AB - Background: Serum thymus and activation-regulated chemokine (TARC) levels are associated with the disease activity of patients with atopic dermatitis (AD) and sensitively reflect short-term changes in skin conditions. The main treatment for AD is topical agent application.Objective: This study investigated the relationship between serum TARC levels and the dosage of topical agents, including corticosteroids and/or tacrolimus, in patients with AD.Methods: The serum TARC levels of 56 AD patients and the amounts of topical agents prescribed to them were investigated retrospectively. The weekly reduction in serum TARC levels and weekly dosage of topical agents among AD patients were compared and their associations were evaluated.Results: The dosage of topical agents was closely related to serum TARC levels. One gram of strong rank steroid or the equivalent amount of steroid/tacrolimus is required to reduce serum TARC levels by 9.94 pg/mL weekly in moderate to severe AD patients. Higher initial TARC levels require more topical agent, which results in a more rapid decrease in TARC levels. The serum TARC levels and eosinophil numbers in peripheral blood are significantly correlated.Conclusion: Serum TARC level improvement and topical agent dosage are strongly correlated. TARC and eosinophil numbers are significantly correlated, but the wider range of TARC levels seems to be clinically more useful for monitoring AD severity. The serum TARC level is a very sensitive biomarker for monitoring the severity and treatment response in AD.

KW - Atopic dermatitis

KW - Serum thymus and activation-regulated chemokine (TARC) levels

KW - Topical corticosteroids

KW - Topical tacrolimus

KW - Total equivalent amounts (TEA)

UR - http://www.scopus.com/inward/record.url?scp=84911927615&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84911927615&partnerID=8YFLogxK

U2 - 10.12932/AP0419.32.3.2014

DO - 10.12932/AP0419.32.3.2014

M3 - Article

C2 - 25268342

AN - SCOPUS:84911927615

SN - 0125-877X

VL - 32

SP - 240

EP - 245

JO - Asian Pacific Journal of Allergy and Immunology

JF - Asian Pacific Journal of Allergy and Immunology

IS - 3

ER -

Reduction of serum TARC levels in atopic dermatitis by topical anti-inflammatory treatments

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this