Reduction-triggered red fluorescent probes for dual-color detection of oligonucleotide sequences

Kazuhiro Furukawa*, Hiroshi Abe, Jin Wang, Miwako Uda, Hiroyuki Koshino, Satoshi Tsuneda, Yoshihiro Ito

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


We have developed a new red fluorogenic compound derived from naphthorhodamine for a reduction-triggered fluorescence probe to sense oligonucleotides. The fluorogenic reaction between naphthorhodamine azide derivatives and reducing reagents such as triphenylphosphine (TPP) on the DNA target does not use any enzyme or reagent, and fluoresces at 650 nm. The probes were used for dual color detection of a single nucleotide difference on the leukemia-related bcr/abl gene.

Original languageEnglish
Pages (from-to)671-677
Number of pages7
JournalOrganic and Biomolecular Chemistry
Issue number4
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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