Reelin and cyclin-dependent kinase 5

Toshio Ohshima

doi:10.1007/978-0-387-76761-1_9

Reelin and cyclin-dependent kinase 5

Toshio Ohshima^*

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Reelin, an extracellular signaling molecule, and cyclin-dependent kinase 5 (Cdk5), a cytoplasmic kinase, are key regulators of normal brain development, including establishment of the complex brain structure. Recent studies have indicated that both Reelin signaling and Cdk5 are also involved in synaptic plasticity and neurodegeneration. In this chapter, I shall describe the functions of Cdk5 in neuronal migration during brain development and present an overview of the relationship of Cdk5 with Reelin signaling based on analyses of mutant mouse models. I shall also refer to the functions of Reelin signaling and Cdk5 in dendrite development, synaptic plasticity, and neurodegeneration.

Original language	English
Title of host publication	Reelin Glycoprotein
Subtitle of host publication	Structure, Biology and Roles in Health and Disease
Publisher	Springer New York
Pages	127-139
Number of pages	13
ISBN (Electronic)	9780387767611
ISBN (Print)	9780387767604
DOIs	https://doi.org/10.1007/978-0-387-76761-1_9
Publication status	Published - 2008 Jan 1

ASJC Scopus subject areas

Medicine(all)
Neuroscience(all)

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10.1007/978-0-387-76761-1_9

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Reelin and cyclin-dependent kinase 5

Abstract

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