@article{8f9fa216393e41d8a20804a6e00c3a1e,
title = "Reformation of thalidomide from its hydrolysis compound via intramolecular dehydration",
abstract = "Thalidomide, a famous chiral drug, can be hydrolyzed into three different compounds depending on the reaction site of hydrolysis. This work presents the reformation of thalidomide from one of the hydrolysis compounds through an intramolecular dehydration reaction in acetonitrile. The difference of dehydration behavior between hydrolysis compounds was rationalized based on molecular structures: The reformable molecule has the preferable geometric environment for intramolecular dehydration.",
keywords = "Hydrolysis, Intramolecular dehydration, Thalidomide",
author = "Takuya Taniguchi and Miri Nakamura and Koichi Tsutao and Kohei Otogawa and Yoshiyuki Ogino and Toru Asahi",
note = "Funding Information: This study was financially supported by a Japan Society for the Promotion of Science Grant-in-Aid for Challenging Exploratory Research (No. 26620019), the Research Fellowship for Young Scientists (No. 14J07160), and the Waseda Research Institute for Science and Engineering (Research for Energy Next) at Waseda University. We would also like to thank the Leading Graduate Program in Science and Engineering at Waseda University. Publisher Copyright: {\textcopyright} 2021 Chemical Society of Japan. All rights reserved.",
year = "2021",
month = jul,
doi = "10.1246/cl.210099",
language = "English",
volume = "50",
pages = "1388--1391",
journal = "Chemistry Letters",
issn = "0366-7022",
publisher = "Chemical Society of Japan",
number = "7",
}