Regioselective synthesis of piceatannol from resveratrol: Catalysis by two-component flavin-dependent monooxygenase HpaBC in whole cells

Toshiki Furuya; Kuniki Kino

doi:10.1016/j.tetlet.2014.03.076

Regioselective synthesis of piceatannol from resveratrol: Catalysis by two-component flavin-dependent monooxygenase HpaBC in whole cells

Toshiki Furuya^*, Kuniki Kino

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Piceatannol, a valuable biologically active stilbene derivative, was efficiently synthesized from resveratrol. Whole-cell catalysis with HpaBC monooxygenase enabled the regioselective hydroxylation of resveratrol to produce 23 mM (5.2 g L^-1) of piceatannol.

Original language	English
Pages (from-to)	2853-2855
Number of pages	3
Journal	Tetrahedron Letters
Volume	55
Issue number	17
DOIs	https://doi.org/10.1016/j.tetlet.2014.03.076
Publication status	Published - 2014 Apr 23

Keywords

HpaBC
Hydroxylation
Monooxygenase
Piceatannol

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2014.03.076

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title = "Regioselective synthesis of piceatannol from resveratrol: Catalysis by two-component flavin-dependent monooxygenase HpaBC in whole cells",

abstract = "Piceatannol, a valuable biologically active stilbene derivative, was efficiently synthesized from resveratrol. Whole-cell catalysis with HpaBC monooxygenase enabled the regioselective hydroxylation of resveratrol to produce 23 mM (5.2 g L-1) of piceatannol.",

keywords = "HpaBC, Hydroxylation, Monooxygenase, Piceatannol",

author = "Toshiki Furuya and Kuniki Kino",

year = "2014",

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T1 - Regioselective synthesis of piceatannol from resveratrol

T2 - Catalysis by two-component flavin-dependent monooxygenase HpaBC in whole cells

AU - Furuya, Toshiki

AU - Kino, Kuniki

PY - 2014/4/23

Y1 - 2014/4/23

N2 - Piceatannol, a valuable biologically active stilbene derivative, was efficiently synthesized from resveratrol. Whole-cell catalysis with HpaBC monooxygenase enabled the regioselective hydroxylation of resveratrol to produce 23 mM (5.2 g L-1) of piceatannol.

AB - Piceatannol, a valuable biologically active stilbene derivative, was efficiently synthesized from resveratrol. Whole-cell catalysis with HpaBC monooxygenase enabled the regioselective hydroxylation of resveratrol to produce 23 mM (5.2 g L-1) of piceatannol.

KW - HpaBC

KW - Hydroxylation

KW - Monooxygenase

KW - Piceatannol

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DO - 10.1016/j.tetlet.2014.03.076

M3 - Article

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SN - 0040-4039

VL - 55

SP - 2853

EP - 2855

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 17

ER -

Regioselective synthesis of piceatannol from resveratrol: Catalysis by two-component flavin-dependent monooxygenase HpaBC in whole cells

Abstract

Keywords

ASJC Scopus subject areas

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