TY - JOUR
T1 - Relation between insulin sensitivity and metabolic abnormalities in Japanese men with BMI of 23-25 kg/m2
AU - Takeno, Kageumi
AU - Tamura, Yoshifumi
AU - Kawaguchi, Minako
AU - Kakehi, Saori
AU - Watanabe, Takahiro
AU - Funayama, Takashi
AU - Furukawa, Yasuhiko
AU - Kaga, Hideyoshi
AU - Yamamoto, Risako
AU - Kim, Maengkyu
AU - Nishitani-Yokoyama, Miho
AU - Shimada, Kazunori
AU - Daida, Hiroyuki
AU - Aoki, Shigeki
AU - Taka, Hikari
AU - Fujimura, Tsutomu
AU - Sawada, Susumu S.
AU - Giacca, Adria
AU - Kanazawa, Akio
AU - Fujitani, Yoshio
AU - Kawamori, Ryuzo
AU - Watada, Hirotaka
N1 - Publisher Copyright:
© 2016 by the Endocrine Society.
PY - 2016/10
Y1 - 2016/10
N2 - Context: Although metabolic abnormalities are often developed in Asians with body mass index (BMI) of 23-25 kg/m2, the characteristics of the nonobese Asians with metabolic abnormality have not been fully understood. Objective: The aim of this study was to investigate the clinical significance of insulin sensitivity in Japanese men with BMI of 23-25 kg/m2. Design and Participants: In this study, we defined hypertension, hyperglycemia, and dyslipidemia as cardiometabolic risk factors (CMRFs). We recruited subjects who met the following selection criteria: men with BMI of 21-23 kg/m2 and no CMRF (n = 24); men with BMI of 23-25 kg/m2 and no CMRF (n = 28), or one CMRF (n = 28), or at least two CMRFs (n = 14); and overweight men with metabolic syndrome (n = 20). Insulin sensitivity (IS) and ectopic fat content in muscle and liver were measured by two-step hyperinsulinemic-euglycemic clamp and 1H-magnetic resonance spectroscopy, respectively. Results: Among subjects with BMI of 23-25 kg/m2, impaired IS in muscle, but not in liver, was found in those with even one CMRF, whereas impaired IS in both muscle and liver was observed in overweight men with metabolic syndrome. Liver fat accumulation and elevated liver enzymes were associated with impaired IS in both muscle and liver in those subjects. Conclusions: Among Japanese men with BMI of 23-25 kg/m2, muscle insulin resistance was present in those with even one CMRF. In this population, liver fat accumulation and/or elevated liver enzymes could be a good marker for impaired IS in both muscle and liver.
AB - Context: Although metabolic abnormalities are often developed in Asians with body mass index (BMI) of 23-25 kg/m2, the characteristics of the nonobese Asians with metabolic abnormality have not been fully understood. Objective: The aim of this study was to investigate the clinical significance of insulin sensitivity in Japanese men with BMI of 23-25 kg/m2. Design and Participants: In this study, we defined hypertension, hyperglycemia, and dyslipidemia as cardiometabolic risk factors (CMRFs). We recruited subjects who met the following selection criteria: men with BMI of 21-23 kg/m2 and no CMRF (n = 24); men with BMI of 23-25 kg/m2 and no CMRF (n = 28), or one CMRF (n = 28), or at least two CMRFs (n = 14); and overweight men with metabolic syndrome (n = 20). Insulin sensitivity (IS) and ectopic fat content in muscle and liver were measured by two-step hyperinsulinemic-euglycemic clamp and 1H-magnetic resonance spectroscopy, respectively. Results: Among subjects with BMI of 23-25 kg/m2, impaired IS in muscle, but not in liver, was found in those with even one CMRF, whereas impaired IS in both muscle and liver was observed in overweight men with metabolic syndrome. Liver fat accumulation and elevated liver enzymes were associated with impaired IS in both muscle and liver in those subjects. Conclusions: Among Japanese men with BMI of 23-25 kg/m2, muscle insulin resistance was present in those with even one CMRF. In this population, liver fat accumulation and/or elevated liver enzymes could be a good marker for impaired IS in both muscle and liver.
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U2 - 10.1210/jc.2016-1650
DO - 10.1210/jc.2016-1650
M3 - Article
C2 - 27383116
AN - SCOPUS:84991702425
SN - 0021-972X
VL - 101
SP - 3676
EP - 3684
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 10
ER -