TY - JOUR
T1 - Relationship between atrial natriuretic peptide and plasma volume during graded exercise with water immersion
AU - Nagashima, K.
AU - Nose, H.
AU - Yoshida, T.
AU - Kawabata, T.
AU - Oda, Y.
AU - Yorimoto, A.
AU - Uemura, O.
AU - Morimoto, T.
PY - 1995
Y1 - 1995
N2 - To assess the relationship between atrial natriuretic peptide (ANP) and the reduction in plasma volume (PV) during exercise, we measured changes in PV and ANP in seven male volunteers during treadmill exercise in air (AE) and with water immersion (WE) together with time control studies of rest in air and in water. Blood samples were collected from a catheter in the antecubital vein at exercise intensities of 32, 49, 65, and 78% of peak oxygen consumption (V̇O2). Plasma ANP in AE increased significantly from the resting value [15 ± 1 (SE) pg/ml] only at 78% of peak V̇O2 (29 ± 5 pg/ml), whereas ANP in WE increased significantly at exercise levels of >49% of peak V̇O2 and reached 68 ± 9 pg/ml at 78% of peak V̇O2. Although PV in AE and WE decreased significantly with V̇O2 of >49% of peak V̇O2 (P < 0.01), the decrease from the resting value in WE was significantly greater than that in AE of >65% of peak V̇O2 (P < 0.01) and the decreases at 78% of peak V̇O2 were -9.7 ± 0.8 and -6.1 ± 1.7%, respectively. The difference in the decrease in PV between AE and WE at corresponding V̇O2 correlated strongly with that in the increase in ANP (r = -0.97; P < 0.01). These results are consistent with the hypothesis that ANP may be involved in the fluid shift from the intra- to extravascular space during exercise.
AB - To assess the relationship between atrial natriuretic peptide (ANP) and the reduction in plasma volume (PV) during exercise, we measured changes in PV and ANP in seven male volunteers during treadmill exercise in air (AE) and with water immersion (WE) together with time control studies of rest in air and in water. Blood samples were collected from a catheter in the antecubital vein at exercise intensities of 32, 49, 65, and 78% of peak oxygen consumption (V̇O2). Plasma ANP in AE increased significantly from the resting value [15 ± 1 (SE) pg/ml] only at 78% of peak V̇O2 (29 ± 5 pg/ml), whereas ANP in WE increased significantly at exercise levels of >49% of peak V̇O2 and reached 68 ± 9 pg/ml at 78% of peak V̇O2. Although PV in AE and WE decreased significantly with V̇O2 of >49% of peak V̇O2 (P < 0.01), the decrease from the resting value in WE was significantly greater than that in AE of >65% of peak V̇O2 (P < 0.01) and the decreases at 78% of peak V̇O2 were -9.7 ± 0.8 and -6.1 ± 1.7%, respectively. The difference in the decrease in PV between AE and WE at corresponding V̇O2 correlated strongly with that in the increase in ANP (r = -0.97; P < 0.01). These results are consistent with the hypothesis that ANP may be involved in the fluid shift from the intra- to extravascular space during exercise.
KW - fluid shift
KW - metabolites
KW - permeability
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U2 - 10.1152/jappl.1995.78.1.217
DO - 10.1152/jappl.1995.78.1.217
M3 - Article
C2 - 7713815
AN - SCOPUS:0028796364
SN - 8750-7587
VL - 78
SP - 217
EP - 224
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
IS - 1
ER -