TY - JOUR
T1 - Relationship between flavonoid structure and reactive oxygen species generation upon ultraviolet and X-ray irradiation
AU - Jiang, Lei
AU - Yanase, Emiko
AU - Mori, Takashi
AU - Kurata, Kanae
AU - Toyama, Michiru
AU - Tsuchiya, Ayaka
AU - Yamauchi, Kosei
AU - Mitsunaga, Tohru
AU - Iwahashi, Hitoshi
AU - Takahashi, Junko
N1 - Funding Information:
X-ray equipment was provided by the Animal Medical Center, Gifu University. This work was partially supported by the Canon Foundation. We would like to thank Editage (www.editage.jp) for English language editing. We would also like to thank Takema Hasegawa and Akihiro Moriyama (United Graduate School of Agricultural Science, Gifu University) for proofreading.
Funding Information:
X-ray equipment was provided by the Animal Medical Center, Gifu University. This work was partially supported by the Canon Foundation . We would like to thank Editage ( www.editage.jp ) for English language editing. We would also like to thank Takema Hasegawa and Akihiro Moriyama (United Graduate School of Agricultural Science, Gifu University) for proofreading.
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - In this research, we aimed to reveal structures related to reactive oxygen species (ROS) generation of flavonoids upon ultraviolet (UV) or X-ray irradiation. ROS production of selected flavonoids was studied by using ROS fluorescence probes. We discuss the relationship between the structures of the flavonoids and the generation of three ROSs, superoxide anion radical (O2 •−), hydroxyl radical (•OH), and singlet oxygen (1O2). Results showed that 2,3-double bond was an key structure for natural flavonoids to generate O2 •−. We also discuss the effects of the ROS scavenging capacities on ROS generation through oxygen radical absorbance capacity (ORAC) tests. Derivatives of quercetin could produce •OH due to differences of ROS scavenging ability. Our results indicated that flavonoids and their derivatives, which were used as antioxidant reagents, can serve as ROS generators upon ultraviolet (UV) or X-ray irradiation.
AB - In this research, we aimed to reveal structures related to reactive oxygen species (ROS) generation of flavonoids upon ultraviolet (UV) or X-ray irradiation. ROS production of selected flavonoids was studied by using ROS fluorescence probes. We discuss the relationship between the structures of the flavonoids and the generation of three ROSs, superoxide anion radical (O2 •−), hydroxyl radical (•OH), and singlet oxygen (1O2). Results showed that 2,3-double bond was an key structure for natural flavonoids to generate O2 •−. We also discuss the effects of the ROS scavenging capacities on ROS generation through oxygen radical absorbance capacity (ORAC) tests. Derivatives of quercetin could produce •OH due to differences of ROS scavenging ability. Our results indicated that flavonoids and their derivatives, which were used as antioxidant reagents, can serve as ROS generators upon ultraviolet (UV) or X-ray irradiation.
KW - Cancer radiotherapy
KW - Free radicals
KW - Non-ionizing and ionizing radiation
KW - ORAC
KW - Radiosensitizer
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U2 - 10.1016/j.jphotochem.2019.112044
DO - 10.1016/j.jphotochem.2019.112044
M3 - Article
AN - SCOPUS:85071128661
SN - 1010-6030
VL - 384
JO - Journal of Photochemistry and Photobiology A: Chemistry
JF - Journal of Photochemistry and Photobiology A: Chemistry
M1 - 112044
ER -
