Relationship of blood pressure and pump flow in an implantable centrifugal blood pump during hypertension

Takehide Akimoto*, Kenji Yamazaki, Philip Litwak, Kenneth N. Litwak, Osamu Tagusari, Toshio Mori, James F. Antaki, Marina V. Kameneva, Mary J. Watach, Mitsuo Umezu, Jun Tomioka, Robert L. Kormos, Hitoshi Koyanagi, Bartley P. Griffith

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


The purpose of this study was to evaluate the real time relationship between pump flow and pump differential pressure (D-P) during experimentally induced hypertension (HT). Two calves (80 and 68 kg) were implanted with the EVAHEART centrifugal blood pump (SunMedical Technology Research Corp., Nagano, Japan) under general anesthesia. Blood pressure (BP) in diastole was increased to 100 mm Hg by norepinephrine to simulate HT. Pump flow, D-P, ECG, and BP were measured at pump speeds of 1,800, 2,100, and 2,300 rpm. All data were separated into systole and diastole, and pump flow during HT was compared with normotensive (NT) conditions at respective pump speeds. Diastolic BP was increased to 99.3 ± 4.1 mm Hg from 66.5 ± 4.4mm Hg (p < 0.01). D-P in systole was under 40 mm Hg (range of change was 10 to 40 mm Hg) even during HT. During NT, the average systolic pump flow volume was 60% of the total pump flow. However, during HT, the average systolic pump flow was 100% of total pump flow volume, although the pump flow volume in systole during HT decreased (33.1 ± 5.7 vs 25.9 ± 4.0 ml/systole, p < 0.01). In diastole, the average flow volume through the pump was 19.6 ± 6.9 ml/diastole during NT and -2.2 ± 11.1 ml/diastole during HT (p < 0.01). The change in pump flow volume due to HT, in diastole, was greater than the change in pump flow in systole at each pump speed (p < 0.001). This study suggests that the decrease of mean pump flow during HT is mainly due to the decrease of the diastolic pump flow and, to a much lesser degree, systolic pump flow.

Original languageEnglish
Pages (from-to)596-599
Number of pages4
JournalASAIO Journal
Issue number5
Publication statusPublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering


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