TY - JOUR
T1 - Replacing sedentary time for physical activity on bone density in patients with chronic kidney disease
AU - Yoshioka, Masaki
AU - Kosaki, Keisei
AU - Matsui, Masahiro
AU - Shibata, Ai
AU - Oka, Koichiro
AU - Kuro-o, Makoto
AU - Saito, Chie
AU - Yamagata, Kunihiro
AU - Maeda, Seiji
N1 - Funding Information:
This work was supported in part by a Grant-in-Aid for Scientific Research KAKENHI from the Ministry of Education, Culture, Sports, Science, and Technology, Japan (19H03995) and MEXT Leading Initiative for Excellent Young Researchers Grant Number JPMXS0320200234. MY and MM were recipients of a Grant-in-Aid for Research Fellowships of Japan Society for the Promotion of Science for Young Scientists (21J10316, 20J20892).
Publisher Copyright:
© 2021, The Japanese Society Bone and Mineral Research.
PY - 2021/11
Y1 - 2021/11
N2 - Introduction: This study aimed to examine the cross-sectional associations of sedentary time and physical activity time with bone density in patients with chronic kidney disease (CKD). The isotemporal substitution (IS) modeling was used to estimate the beneficial effects of behavioral changes (e.g., replacing sedentary time with physical activity time) on bone density in these patients. Materials and methods: A total of 92 patients with CKD (age: 65 ± 9 years; estimated glomerular filtration rate: 57 ± 22 mL/min/1.73 m2) were included in this cross-sectional study. The times spent in sedentary behavior (SB), light-intensity physical activity (LPA), and moderate- to vigorous-intensity physical activity (MVPA) were assessed using a triaxial accelerometer. Through quantitative ultrasound measurements, the stiffness index, as a measure of bone density, was calculated using the speed of sound and broadband ultrasound attenuation. Results: In multivariate analyses, the stiffness index was beneficially associated with the MVPA time (β = 0.748), but was not significantly associated with the SB and LPA times. The IS models showed that replacing 10 min/day of SB with the equivalent LPA time was not significantly associated with the stiffness index; however, replacing 10 min/day of SB with the equivalent MVPA time was beneficially associated with the stiffness index (β = 0.804). Conclusion: These results suggest that a small increase in MVPA time (e.g., 10 min/day) may attenuate the decline in bone density in patients with CKD. Our findings may provide insight for the development of novel strategies for improving bone health in patients with CKD.
AB - Introduction: This study aimed to examine the cross-sectional associations of sedentary time and physical activity time with bone density in patients with chronic kidney disease (CKD). The isotemporal substitution (IS) modeling was used to estimate the beneficial effects of behavioral changes (e.g., replacing sedentary time with physical activity time) on bone density in these patients. Materials and methods: A total of 92 patients with CKD (age: 65 ± 9 years; estimated glomerular filtration rate: 57 ± 22 mL/min/1.73 m2) were included in this cross-sectional study. The times spent in sedentary behavior (SB), light-intensity physical activity (LPA), and moderate- to vigorous-intensity physical activity (MVPA) were assessed using a triaxial accelerometer. Through quantitative ultrasound measurements, the stiffness index, as a measure of bone density, was calculated using the speed of sound and broadband ultrasound attenuation. Results: In multivariate analyses, the stiffness index was beneficially associated with the MVPA time (β = 0.748), but was not significantly associated with the SB and LPA times. The IS models showed that replacing 10 min/day of SB with the equivalent LPA time was not significantly associated with the stiffness index; however, replacing 10 min/day of SB with the equivalent MVPA time was beneficially associated with the stiffness index (β = 0.804). Conclusion: These results suggest that a small increase in MVPA time (e.g., 10 min/day) may attenuate the decline in bone density in patients with CKD. Our findings may provide insight for the development of novel strategies for improving bone health in patients with CKD.
KW - Bone health
KW - Isotemporal substitution
KW - Physical activity time
KW - Renal dysfunction
KW - Sedentary time
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U2 - 10.1007/s00774-021-01255-w
DO - 10.1007/s00774-021-01255-w
M3 - Article
C2 - 34319455
AN - SCOPUS:85111537984
SN - 0914-8779
VL - 39
SP - 1091
EP - 1100
JO - Journal of Bone and Mineral Metabolism
JF - Journal of Bone and Mineral Metabolism
IS - 6
ER -
