TY - JOUR
T1 - Research and development of magnetic drug delivery system using bulk high temperature superconducting magnet
AU - Nishijima, Shigehiro
AU - Mishima, Fumihito
AU - Tabata, Yasuhiko
AU - Iseki, Hiroshi
AU - Muragaki, Yoshihiro
AU - Sasaki, Akira
AU - Saho, Norihide
N1 - Funding Information:
Manuscript received August 20, 2008. First published June 23, 2009; current version published July 15, 2009. This work was supported in part by NEDO under R/D Project on Next-Generation DDS Treatment Systems for Malignant Tumors, R/D on Next-Generation DDS Treatment Systems for Deep Therapy. S. Nishijima and F. Mishima are with Division of Sustainable Energy and Environmental Engineering, Osaka University, Osaka 565-0871, Japan (e-mail: nishijima@see.eng.osaka-u.ac.jp). Y. Tabata is with the Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Science, Kyoto University, Japan. H. Iseki and Y. Muragaki are with Faculty of Advanced Techno-Surgery, Institute of Advanced Biomedical Engineering and Science, Graduate School of Medicine, Department of Neurosurgery, Neurological Institute, Tokyo Women’s Medical University, Japan. A. Sasaki and J. Kubota are with Hitachi Medical Corp., Japan. N. Saho is with Hitachi, Ltd., Japan. Color versions of one or more of the figures in this paper are available online at http://ieeexplore.ieee.org. Digital Object Identifier 10.1109/TASC.2009.2019288
PY - 2009/6
Y1 - 2009/6
N2 - The magnetic force control of the drug motion in the body has been studied in the current work. The calculation was made to study the possibility of the magnetic force control of the drag motion from outside of the body. The condition which enables the magnetic force control was clarified. The magnetic drug delivery system (MDDS) was demonstrated to be possible using the rat and permanent magnet and the validity of the calculation was confirmed by experiment. The magnetite suspension was introduced into a liver through portal vein in the rat experiment. A permanent magnet was used to navigate the magnetite. The navigation and accumulation of the magnetite was successfully performed. Based on the results, the MDDS experiment was made with an HTS magnet for a large-sized animal, pig. The HTS magnet of which size was 45 mm in diameter and 90 mm in length produced 5 T at 38 K. The suspension of the magnetite was injected into the blood vessel of the pig. It was confirmed that the magnetite was successfully navigated and/or accumulated by the HTS magnet.
AB - The magnetic force control of the drug motion in the body has been studied in the current work. The calculation was made to study the possibility of the magnetic force control of the drag motion from outside of the body. The condition which enables the magnetic force control was clarified. The magnetic drug delivery system (MDDS) was demonstrated to be possible using the rat and permanent magnet and the validity of the calculation was confirmed by experiment. The magnetite suspension was introduced into a liver through portal vein in the rat experiment. A permanent magnet was used to navigate the magnetite. The navigation and accumulation of the magnetite was successfully performed. Based on the results, the MDDS experiment was made with an HTS magnet for a large-sized animal, pig. The HTS magnet of which size was 45 mm in diameter and 90 mm in length produced 5 T at 38 K. The suspension of the magnetite was injected into the blood vessel of the pig. It was confirmed that the magnetite was successfully navigated and/or accumulated by the HTS magnet.
KW - Accumulation of magnetic seeded drug
KW - Animal experiment
KW - Bulk HTS magnet
KW - Magnetic drug delivery system
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U2 - 10.1109/TASC.2009.2019288
DO - 10.1109/TASC.2009.2019288
M3 - Article
AN - SCOPUS:68649123772
SN - 1051-8223
VL - 19
SP - 2257
EP - 2260
JO - IEEE Transactions on Applied Superconductivity
JF - IEEE Transactions on Applied Superconductivity
IS - 3
M1 - 5109597
ER -