Respiratory flow in a realistic tracheostenosis model

Toshihiro Sera*, Sunao Satoh, Hirohisa Horinouchi, Koichi Kobayashi, Kazuo Tanishita

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


The possible mechanism of wheeze generation in tracheostenosis was identified by measuring inspiratory and expiratory flow in a "morphological and distensible" realistic tracheostenosis model. The shape of the model was based on CT (Computed Tomography) images of a patient that had tracheostenosis. A trachea consists of tracheal cartilage rings and smooth muscle. Spatial variation of wall distensibility was achieved in the model by varying the wall thickness based on the elastic modulus measured in pig air-ways. The spatial variation influenced the flow in the airway and the turbulence production rate decreased faster at smooth muscles. Using the model, we investigated the mechanism of wheeze generation by focusing on the turbulence intensity. The turbulence intensity in expiratory flow was about twice that in inspiratory flow, and larger vortices existed in post-stenosis in expiratory flow, and thus might contribute to wheeze generation.

Original languageEnglish
Pages (from-to)461-471
Number of pages11
JournalJournal of Biomechanical Engineering
Issue number4
Publication statusPublished - 2003 Aug
Externally publishedYes

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biophysics


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