Rhodamine-based fluorogenic probe for imaging biological thiol

Aya Shibata, Kazuhiro Furukawa, Hiroshi Abe*, Satoshi Tsuneda, Yoshihiro Ito

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

95 Citations (Scopus)


We have developed a new fluorescent probe for biological thiol. The probe was synthesized by the modification of the 2,4-dinitrobenzenesulfonyl group with rhodamine 110. The selective detection of thiol species such as cysteine or glutathione was achieved in biological conditions. Moreover, the probe was successfully applied to the imaging of thiol species in living human cells.

Original languageEnglish
Pages (from-to)2246-2249
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number7
Publication statusPublished - 2008 Apr 1


  • Fluorescence
  • Imaging
  • Probe
  • Synthesis
  • Thiol

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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