Rhodium complex-catalyzed Pauson-Khand-type reaction with aldehydes as a CO source

Takanori Shibata*, Natsuko Toshida, Kentaro Takagi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

138 Citations (Scopus)


With aldehydes as a CO source under solvent-free conditions, rhodium complex efficiently catalyzed an intramolecular carbonylative alkene-alkyne coupling (Pauson-Khand-type reaction) and various bicyclic enones were obtained in high yield. Experiments under argon flow and a 13C-labeling experiment suggested that almost no free carbon monoxide was generated in this reaction. When noncationic rhodium complex with chiral phosphine was used as a chiral catalyst, the reaction proceeded enantioselectively to give various chiral cyclopentenones in up to 90% ee under solvent-free conditions.

Original languageEnglish
Pages (from-to)7446-7450
Number of pages5
JournalJournal of Organic Chemistry
Issue number21
Publication statusPublished - 2002 Oct 18
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry


Dive into the research topics of 'Rhodium complex-catalyzed Pauson-Khand-type reaction with aldehydes as a CO source'. Together they form a unique fingerprint.

Cite this