TY - JOUR
T1 - Role of inositol 1,4,5-trisphosphate receptor in ventral signaling in xenopus embryos
AU - Kume, Shoen
AU - Muto, Akira
AU - Inoue, Takafumi
AU - Suga, Kei
AU - Okano, Hideyuki
AU - Mikoshiba, Katsuhiko
PY - 1997/12/12
Y1 - 1997/12/12
N2 - The inositol 1,4,5-trisphosphate (IP3) receptor is a calcium ion channel involved in the release of free Ca2+ from intracellular stores. For analysis of the role of IP3-induced Ca2+ release (IICR) on patterning of the embryonic body, monoclonal antibodies that inhibit IICR were produced. Injection of these blocking antibodies into the ventral part of early Xenopus embryos induced modest dorsal differentiation. A close correlation between IICR blocking potencies and ectopic dorsal axis induction frequency suggests that an active IP3-Ca2+ signal may participate in the modulation of ventral differentiation.
AB - The inositol 1,4,5-trisphosphate (IP3) receptor is a calcium ion channel involved in the release of free Ca2+ from intracellular stores. For analysis of the role of IP3-induced Ca2+ release (IICR) on patterning of the embryonic body, monoclonal antibodies that inhibit IICR were produced. Injection of these blocking antibodies into the ventral part of early Xenopus embryos induced modest dorsal differentiation. A close correlation between IICR blocking potencies and ectopic dorsal axis induction frequency suggests that an active IP3-Ca2+ signal may participate in the modulation of ventral differentiation.
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U2 - 10.1126/science.278.5345.1940
DO - 10.1126/science.278.5345.1940
M3 - Article
C2 - 9395395
AN - SCOPUS:0031439813
SN - 0036-8075
VL - 278
SP - 1940
EP - 1943
JO - Science
JF - Science
IS - 5345
ER -