Roles of A- and D-type K channels in EPSP integration at a model dendrite

Hiroshi Takagi*, Ryo Sato, Masaya Mori, Etsuro Ito, Hideo Suzuki

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


We examined the roles of A- and D-type K channels in the integration of EPSPs, particularly EPSP reduction, in a model dendrite using a computer simulation program (NEURON), instead of conventional electrophysiological methods which present technical difficulties. We obtained two important results: (1) KD channels play a crucial role in every synaptic input event, and (2) KA channels affect reduction of the second EPSP only when the second synaptic input is applied with a short interval (≤100 ms). These results suggest that KD channels, which have not yet been analyzed experimentally, play a major role in synaptic integration in dendrites by altering their cable properties.

Original languageEnglish
Pages (from-to)165-168
Number of pages4
JournalNeuroscience Letters
Issue number3
Publication statusPublished - 1998 Oct 2
Externally publishedYes


  • Cable theory
  • Computer simulation
  • Dendritic Integration
  • K Channels

ASJC Scopus subject areas

  • General Neuroscience


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