rs2802292 polymorphism in the FOXO3A gene and exceptional longevity in two ethnically distinct cohorts

Noriyuki Fuku, Roberto Díaz-Peña*, Yasumichi Arai, Yukiko Abe, Helios Pareja-Galeano, Fabián Sanchis-Gomar, Alejandro Santos-Lozano, Hirofumi Zempo, Hisashi Naito, Haruka Murakami, Motohiko Miyachi, Letizia Venturini, Giovanni Ricevuti, Hirose Nobuyoshi, Enzo Emanuele, Alejandro Lucia

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Objectives Previous studies have indicated that the rs2802292 polymorphism in the human forkhead box O3A (FOXO3A) gene might be associated with exceptional longevity (EL, i.e., living 100+ years), although the results are conflicting. Study design and main outcome measures Using a case-control design, we investigated the distribution of the rs2802292 polymorphism in two ethnically distinct cohorts of centenarians (cases) and younger adults (controls). The first cohort included Japanese individuals (733 centenarians and 820 controls) and the second was from Northern Italy (79 disease-free centenarians and 316 controls). Results No statistically significant association was found between the rs2802292 polymorphism and EL in either cohort (either examined in their entirety or in a sex-based analysis). Conclusions In light of our negative findings, further research and resequencing efforts are needed to shed more light on the potential association between EL and FOXO3A polymorphisms.

Original languageEnglish
Pages (from-to)110-114
Number of pages5
Publication statusPublished - 2016 Oct 1
Externally publishedYes


  • Aging
  • Centenarian
  • FOXO3A
  • Genetics
  • Longevity
  • Polymorphism

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Obstetrics and Gynaecology


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