Salivary 3-methoxy-4-hydroxyphenylglycol increases after awakening in healthy young adults

Nagisa Sugaya; Shuhei Izawa; Ryuichiro Yamamoto; Namiko Ogawa; Jumpei Yajima; Hisayoshi Okamura; Satoshi Horiuchi; Akira Tsuda; Shinobu Nomura

doi:10.1111/psyp.12330

Salivary 3-methoxy-4-hydroxyphenylglycol increases after awakening in healthy young adults

Nagisa Sugaya^*, Shuhei Izawa, Ryuichiro Yamamoto, Namiko Ogawa, Jumpei Yajima, Hisayoshi Okamura, Satoshi Horiuchi, Akira Tsuda, Shinobu Nomura

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) may reflect central noradrenergic activity. In this study, we investigated salivary MHPG changes after awakening, and explored their relationships with cortisol and peripheral autonomic activity. The participants were 25 college students. Saliva samples were collected on awakening and 30min after awakening to determine MHPG and cortisol. Ambulatory electrocardiograms were obtained to assess heart rate, cardiac sympathetic index (CSI), and cardiac vagal index (CVI) before and after awakening. MHPG levels increased significantly during the first 30min after awakening. Similarly, cortisol, heart rate, and CSI increased during the 30min after awakening, but changes in MHPG did not correlate with changes in cortisol, heart rate, CSI, and CVI during that period. This study demonstrated that salivary MHPG levels increase after awakening, in common with cortisol, heart rate, and cardiac sympathetic activity.

Original language	English
Pages (from-to)	425-428
Number of pages	4
Journal	Psychophysiology
Volume	52
Issue number	3
DOIs	https://doi.org/10.1111/psyp.12330
Publication status	Published - 2015 Mar 1

Keywords

Awakening
Central noradrenergic metabolism
MHPG
Saliva

ASJC Scopus subject areas

Physiology
Physiology (medical)
Experimental and Cognitive Psychology
Neuropsychology and Physiological Psychology
Arts and Humanities (miscellaneous)
Developmental and Educational Psychology

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10.1111/psyp.12330

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title = "Salivary 3-methoxy-4-hydroxyphenylglycol increases after awakening in healthy young adults",

abstract = "Levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) may reflect central noradrenergic activity. In this study, we investigated salivary MHPG changes after awakening, and explored their relationships with cortisol and peripheral autonomic activity. The participants were 25 college students. Saliva samples were collected on awakening and 30min after awakening to determine MHPG and cortisol. Ambulatory electrocardiograms were obtained to assess heart rate, cardiac sympathetic index (CSI), and cardiac vagal index (CVI) before and after awakening. MHPG levels increased significantly during the first 30min after awakening. Similarly, cortisol, heart rate, and CSI increased during the 30min after awakening, but changes in MHPG did not correlate with changes in cortisol, heart rate, CSI, and CVI during that period. This study demonstrated that salivary MHPG levels increase after awakening, in common with cortisol, heart rate, and cardiac sympathetic activity.",

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AU - Sugaya, Nagisa

AU - Izawa, Shuhei

AU - Yamamoto, Ryuichiro

AU - Ogawa, Namiko

AU - Yajima, Jumpei

AU - Okamura, Hisayoshi

AU - Horiuchi, Satoshi

AU - Tsuda, Akira

AU - Nomura, Shinobu

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) may reflect central noradrenergic activity. In this study, we investigated salivary MHPG changes after awakening, and explored their relationships with cortisol and peripheral autonomic activity. The participants were 25 college students. Saliva samples were collected on awakening and 30min after awakening to determine MHPG and cortisol. Ambulatory electrocardiograms were obtained to assess heart rate, cardiac sympathetic index (CSI), and cardiac vagal index (CVI) before and after awakening. MHPG levels increased significantly during the first 30min after awakening. Similarly, cortisol, heart rate, and CSI increased during the 30min after awakening, but changes in MHPG did not correlate with changes in cortisol, heart rate, CSI, and CVI during that period. This study demonstrated that salivary MHPG levels increase after awakening, in common with cortisol, heart rate, and cardiac sympathetic activity.

AB - Levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) may reflect central noradrenergic activity. In this study, we investigated salivary MHPG changes after awakening, and explored their relationships with cortisol and peripheral autonomic activity. The participants were 25 college students. Saliva samples were collected on awakening and 30min after awakening to determine MHPG and cortisol. Ambulatory electrocardiograms were obtained to assess heart rate, cardiac sympathetic index (CSI), and cardiac vagal index (CVI) before and after awakening. MHPG levels increased significantly during the first 30min after awakening. Similarly, cortisol, heart rate, and CSI increased during the 30min after awakening, but changes in MHPG did not correlate with changes in cortisol, heart rate, CSI, and CVI during that period. This study demonstrated that salivary MHPG levels increase after awakening, in common with cortisol, heart rate, and cardiac sympathetic activity.

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Salivary 3-methoxy-4-hydroxyphenylglycol increases after awakening in healthy young adults

Abstract

Keywords

ASJC Scopus subject areas

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