Salivary 3-methoxy-4-hydroxyphenylglycol increases after awakening in healthy young adults

Nagisa Sugaya*, Shuhei Izawa, Ryuichiro Yamamoto, Namiko Ogawa, Jumpei Yajima, Hisayoshi Okamura, Satoshi Horiuchi, Akira Tsuda, Shinobu Nomura

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)


    Levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) may reflect central noradrenergic activity. In this study, we investigated salivary MHPG changes after awakening, and explored their relationships with cortisol and peripheral autonomic activity. The participants were 25 college students. Saliva samples were collected on awakening and 30min after awakening to determine MHPG and cortisol. Ambulatory electrocardiograms were obtained to assess heart rate, cardiac sympathetic index (CSI), and cardiac vagal index (CVI) before and after awakening. MHPG levels increased significantly during the first 30min after awakening. Similarly, cortisol, heart rate, and CSI increased during the 30min after awakening, but changes in MHPG did not correlate with changes in cortisol, heart rate, CSI, and CVI during that period. This study demonstrated that salivary MHPG levels increase after awakening, in common with cortisol, heart rate, and cardiac sympathetic activity.

    Original languageEnglish
    Pages (from-to)425-428
    Number of pages4
    Issue number3
    Publication statusPublished - 2015 Mar 1


    • Awakening
    • Central noradrenergic metabolism
    • MHPG
    • Saliva

    ASJC Scopus subject areas

    • Physiology
    • Physiology (medical)
    • Experimental and Cognitive Psychology
    • Neuropsychology and Physiological Psychology
    • Arts and Humanities (miscellaneous)
    • Developmental and Educational Psychology


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