Self-assembling DNA-peptide hybrids: Morphological consequences of oligonucleotide grafting to a pathogenic amyloid fibrils forming dipeptide

Nidhi Gour; Dawid Kedracki; Ilyès Safir; Kien Xuan Ngo; Corinne Vebert-Nardin

doi:10.1039/c2cc31458d

Self-assembling DNA-peptide hybrids: Morphological consequences of oligonucleotide grafting to a pathogenic amyloid fibrils forming dipeptide

Nidhi Gour, Dawid Kedracki, Ilyès Safir, Kien Xuan Ngo, Corinne Vebert-Nardin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

For the very first time, highly efficient synthesis of DNA-peptide hybrids to scaffold self-assembled nanostructures is described. Oligonucleotide conjugation to the diphenylalanine dipeptide triggers a morphological transition from fibrillar to vesicular structures which may potentially be used as delivery vehicles, since they exhibit pH triggered release.

Original language	English
Pages (from-to)	5440-5442
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	44
DOIs	https://doi.org/10.1039/c2cc31458d
Publication status	Published - 2012 Jun 4
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c2cc31458d

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AU - Ngo, Kien Xuan

AU - Vebert-Nardin, Corinne

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AB - For the very first time, highly efficient synthesis of DNA-peptide hybrids to scaffold self-assembled nanostructures is described. Oligonucleotide conjugation to the diphenylalanine dipeptide triggers a morphological transition from fibrillar to vesicular structures which may potentially be used as delivery vehicles, since they exhibit pH triggered release.

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Self-assembling DNA-peptide hybrids: Morphological consequences of oligonucleotide grafting to a pathogenic amyloid fibrils forming dipeptide

Abstract

ASJC Scopus subject areas

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