Sequence analysis of a Kpnl family member near the 3′ end of human β-globin gene

Masahira Hattori; Saburo Hidaka; Yoshiyuki Sakaki

doi:10.1093/nar/13.21.7813

Sequence analysis of a Kpnl family member near the 3′ end of human β-globin gene

Masahira Hattori^*, Saburo Hidaka, Yoshiyuki Sakaki

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

116 Citations (Scopus)

Abstract

We determined the complete nucleotide sequence (6125 bp) of a full-length member of human KpnI family, designated TβG41, which is located about 3 kb downstream from the β-globin gene. Comparison of the sequence with the KpnI family sequence compiled by Singer revealed that a new 131 bp sequence is present in the TβG41. Hybridization analyses showed that a few thousand of human KpnI family members are carrying this additional sequence. Computer search of DNA databases for TβG41-homologous sequence showed that some TβG41-homologous sequences were closely associated with pseudogenes. The TβG41 sequence also showed significant sequence homology with ChBlyml, a transferrin-like transforming gene of chicken. Furthermore, an amino acid sequence deduced from the TβG41 nucleotide sequence revealed a relatively-high homology to those of human transferrin and lactotransferrin.

Original language	English
Pages (from-to)	7813-7827
Number of pages	15
Journal	Nucleic Acids Research
Volume	13
Issue number	21
DOIs	https://doi.org/10.1093/nar/13.21.7813
Publication status	Published - 1985 Nov 11
Externally published	Yes

ASJC Scopus subject areas

Statistics, Probability and Uncertainty
Applied Mathematics
Health, Toxicology and Mutagenesis
Toxicology
Genetics(clinical)
Genetics

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title = "Sequence analysis of a Kpnl family member near the 3′ end of human β-globin gene",

abstract = "We determined the complete nucleotide sequence (6125 bp) of a full-length member of human KpnI family, designated TβG41, which is located about 3 kb downstream from the β-globin gene. Comparison of the sequence with the KpnI family sequence compiled by Singer revealed that a new 131 bp sequence is present in the TβG41. Hybridization analyses showed that a few thousand of human KpnI family members are carrying this additional sequence. Computer search of DNA databases for TβG41-homologous sequence showed that some TβG41-homologous sequences were closely associated with pseudogenes. The TβG41 sequence also showed significant sequence homology with ChBlyml, a transferrin-like transforming gene of chicken. Furthermore, an amino acid sequence deduced from the TβG41 nucleotide sequence revealed a relatively-high homology to those of human transferrin and lactotransferrin.",

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AU - Hattori, Masahira

AU - Hidaka, Saburo

AU - Sakaki, Yoshiyuki

PY - 1985/11/11

Y1 - 1985/11/11

N2 - We determined the complete nucleotide sequence (6125 bp) of a full-length member of human KpnI family, designated TβG41, which is located about 3 kb downstream from the β-globin gene. Comparison of the sequence with the KpnI family sequence compiled by Singer revealed that a new 131 bp sequence is present in the TβG41. Hybridization analyses showed that a few thousand of human KpnI family members are carrying this additional sequence. Computer search of DNA databases for TβG41-homologous sequence showed that some TβG41-homologous sequences were closely associated with pseudogenes. The TβG41 sequence also showed significant sequence homology with ChBlyml, a transferrin-like transforming gene of chicken. Furthermore, an amino acid sequence deduced from the TβG41 nucleotide sequence revealed a relatively-high homology to those of human transferrin and lactotransferrin.

AB - We determined the complete nucleotide sequence (6125 bp) of a full-length member of human KpnI family, designated TβG41, which is located about 3 kb downstream from the β-globin gene. Comparison of the sequence with the KpnI family sequence compiled by Singer revealed that a new 131 bp sequence is present in the TβG41. Hybridization analyses showed that a few thousand of human KpnI family members are carrying this additional sequence. Computer search of DNA databases for TβG41-homologous sequence showed that some TβG41-homologous sequences were closely associated with pseudogenes. The TβG41 sequence also showed significant sequence homology with ChBlyml, a transferrin-like transforming gene of chicken. Furthermore, an amino acid sequence deduced from the TβG41 nucleotide sequence revealed a relatively-high homology to those of human transferrin and lactotransferrin.

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Sequence analysis of a Kpnl family member near the 3′ end of human β-globin gene

Abstract

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