Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice

Takayuki Matsumura; Tadayoshi Ikebe; Koji Arikawa; Masahito Hosokawa; Michio Aiko; Aoi Iguchi; Ikuko Togashi; Sayaka Kai; Sakiko Ohara; Naoya Ohara; Makoto Ohnishi; Haruo Watanabe; Kazuo Kobayashi; Haruko Takeyama; Sho Yamasaki; Yoshimasa Takahashi; Manabu Ato

doi:10.1016/j.celrep.2019.03.056

Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice

Takayuki Matsumura^*, Tadayoshi Ikebe, Koji Arikawa, Masahito Hosokawa, Michio Aiko, Aoi Iguchi, Ikuko Togashi, Sayaka Kai, Sakiko Ohara, Naoya Ohara, Makoto Ohnishi, Haruo Watanabe, Kazuo Kobayashi, Haruko Takeyama, Sho Yamasaki, Yoshimasa Takahashi, Manabu Ato

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Matsumura et al. show that γIMCs sequentially sense group A Streptococcus (GAS) through TLR2 and Mincle. Specifically, TLR2-triggered production of IL-6 functions as an intermediate that amplifies Mincle expression to maximize host protection through IFN-γ production. The sequential sensing is a distinct feature in γIMCs following severe invasive GAS infection.

Original language	English
Pages (from-to)	561-571.e6
Journal	Cell Reports
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/j.celrep.2019.03.056
Publication status	Published - 2019 Apr 9

Keywords

C-type lectin receptors
Toll-like receptors
cytokines
group A Streptococcus infections
immature myeloid cells

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.celrep.2019.03.056

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Matsumura, T., Ikebe, T., Arikawa, K., Hosokawa, M., Aiko, M., Iguchi, A., Togashi, I., Kai, S., Ohara, S., Ohara, N., Ohnishi, M., Watanabe, H., Kobayashi, K., Takeyama, H., Yamasaki, S., Takahashi, Y., & Ato, M. (2019). Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice. Cell Reports, 27(2), 561-571.e6. https://doi.org/10.1016/j.celrep.2019.03.056

Matsumura, T, Ikebe, T, Arikawa, K, Hosokawa, M, Aiko, M, Iguchi, A, Togashi, I, Kai, S, Ohara, S, Ohara, N, Ohnishi, M, Watanabe, H, Kobayashi, K, Takeyama, H, Yamasaki, S, Takahashi, Y & Ato, M 2019, 'Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice', Cell Reports, vol. 27, no. 2, pp. 561-571.e6. https://doi.org/10.1016/j.celrep.2019.03.056

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abstract = "Matsumura et al. show that γIMCs sequentially sense group A Streptococcus (GAS) through TLR2 and Mincle. Specifically, TLR2-triggered production of IL-6 functions as an intermediate that amplifies Mincle expression to maximize host protection through IFN-γ production. The sequential sensing is a distinct feature in γIMCs following severe invasive GAS infection.",

keywords = "C-type lectin receptors, Toll-like receptors, cytokines, group A Streptococcus infections, immature myeloid cells",

author = "Takayuki Matsumura and Tadayoshi Ikebe and Koji Arikawa and Masahito Hosokawa and Michio Aiko and Aoi Iguchi and Ikuko Togashi and Sayaka Kai and Sakiko Ohara and Naoya Ohara and Makoto Ohnishi and Haruo Watanabe and Kazuo Kobayashi and Haruko Takeyama and Sho Yamasaki and Yoshimasa Takahashi and Manabu Ato",

note = "Funding Information: We thank Ryoko Itami, Yoko Nakamura, Yukari Takahashi, Tadasu Tsuchiya, Takuro Matsuzoe, Hiroko Otake, Kazusa Inoue, Mayu Uchida, and Chikako Sakanashi for technical support. This research was supported by Japan Society for the Promotion of Science ( JSPS) KAKENHI ( JP25460085 and JP16K09952 to T.M.) and Japan Agency for Medical Research and Development (AMED) ( JP18fk0108044 to T.M. and T.I. and JP18am0101104 to H.T.). Publisher Copyright: {\textcopyright} 2019 The Author(s)",

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doi = "10.1016/j.celrep.2019.03.056",

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AU - Matsumura, Takayuki

AU - Ikebe, Tadayoshi

AU - Arikawa, Koji

AU - Hosokawa, Masahito

AU - Aiko, Michio

AU - Iguchi, Aoi

AU - Togashi, Ikuko

AU - Kai, Sayaka

AU - Ohara, Sakiko

AU - Ohara, Naoya

AU - Ohnishi, Makoto

AU - Watanabe, Haruo

AU - Kobayashi, Kazuo

AU - Takeyama, Haruko

AU - Yamasaki, Sho

AU - Takahashi, Yoshimasa

AU - Ato, Manabu

N1 - Funding Information: We thank Ryoko Itami, Yoko Nakamura, Yukari Takahashi, Tadasu Tsuchiya, Takuro Matsuzoe, Hiroko Otake, Kazusa Inoue, Mayu Uchida, and Chikako Sakanashi for technical support. This research was supported by Japan Society for the Promotion of Science ( JSPS) KAKENHI ( JP25460085 and JP16K09952 to T.M.) and Japan Agency for Medical Research and Development (AMED) ( JP18fk0108044 to T.M. and T.I. and JP18am0101104 to H.T.). Publisher Copyright: © 2019 The Author(s)

PY - 2019/4/9

Y1 - 2019/4/9

N2 - Matsumura et al. show that γIMCs sequentially sense group A Streptococcus (GAS) through TLR2 and Mincle. Specifically, TLR2-triggered production of IL-6 functions as an intermediate that amplifies Mincle expression to maximize host protection through IFN-γ production. The sequential sensing is a distinct feature in γIMCs following severe invasive GAS infection.

AB - Matsumura et al. show that γIMCs sequentially sense group A Streptococcus (GAS) through TLR2 and Mincle. Specifically, TLR2-triggered production of IL-6 functions as an intermediate that amplifies Mincle expression to maximize host protection through IFN-γ production. The sequential sensing is a distinct feature in γIMCs following severe invasive GAS infection.

KW - C-type lectin receptors

KW - Toll-like receptors

KW - cytokines

KW - group A Streptococcus infections

KW - immature myeloid cells

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Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice

Abstract

Keywords

ASJC Scopus subject areas

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