Shear stress distribution on the surface of endothelial cells during flow-induced morphological remodeling

Shuichiro Fukushima*, Hideki Fujioka, Kazuo Tanishita

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Morphological remodeling of endothelial cells that was induced by blood flow is considered an adaptive response to a mechanical stimulus. To determine the mechanisms of the response, we examined how shear stress on the surface of the same group of cells changed. The surface geometry of the cells was measured by confocal laser scanning microscopy, and the shear stress distribution on the measured cell surface was determined using the flow field simulated by computational fluid dynamics. When the cells, which were polygonal without alignment at the beginning of the flow exposure, elongated and aligned in the flow direction, the mean shear stress of the cells decreased with time. However, there were some cells whose mean shear stress was increased, and the morphological change of each cell was not always adaptive. The results show the importance of interaction with surrounding cells to the adaptive response as demonstrated in the endothelial layer.

Original languageEnglish
Pages (from-to)1275-1283
Number of pages9
JournalJSME International Journal, Series C: Mechanical Systems, Machine Elements and Manufacturing
Issue number4
Publication statusPublished - 2003 Dec
Externally publishedYes


  • Adaptive remodeling
  • Bio-fluid mechanics
  • Computational fluid dynamics
  • Endothelial cell
  • Shape measurement
  • Shear flow

ASJC Scopus subject areas

  • Industrial and Manufacturing Engineering
  • Mechanical Engineering


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