Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata

Shuhei Murayama; Yasufumi Imae; Kentaro Takada; Jo Kikuchi; Yoichi Nakao; Rob W.M. Van Soest; Shigeru Okada; Shigeki Matsunaga

doi:10.1016/j.bmc.2011.06.052

Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata

Shuhei Murayama, Yasufumi Imae, Kentaro Takada, Jo Kikuchi, Yoichi Nakao, Rob W.M. Van Soest, Shigeru Okada, Shigeki Matsunaga^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Two dimeric steroid derivatives, shishicrellastatin A (1) and B (2), have been isolated as cathepsin B inhibitors from the marine sponge Crella (Yvesia) spinulata. Their structures were determined by interpretation of spectroscopic data. Shishicrellastatins inhibit cathepsin B with an IC ₅₀ value of 8 μg/mL each.

Original language	English
Pages (from-to)	6594-6598
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry
Volume	19
Issue number	22
DOIs	https://doi.org/10.1016/j.bmc.2011.06.052
Publication status	Published - 2011 Nov 15
Externally published	Yes

Keywords

Cathepsin B
Crellastatin
Dimeric
Sponge
Steroid
Structure elucidation

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmc.2011.06.052

Cite this

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title = "Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata",

abstract = "Two dimeric steroid derivatives, shishicrellastatin A (1) and B (2), have been isolated as cathepsin B inhibitors from the marine sponge Crella (Yvesia) spinulata. Their structures were determined by interpretation of spectroscopic data. Shishicrellastatins inhibit cathepsin B with an IC 50 value of 8 μg/mL each.",

keywords = "Cathepsin B, Crellastatin, Dimeric, Sponge, Steroid, Structure elucidation",

author = "Shuhei Murayama and Yasufumi Imae and Kentaro Takada and Jo Kikuchi and Yoichi Nakao and {Van Soest}, {Rob W.M.} and Shigeru Okada and Shigeki Matsunaga",

note = "Funding Information: We thank the officers and crew of T/S Toyoshio-maru of Hiroshima University for their assistance in collecting the sponge. We thank Kanji Hori for the arrangement of the cruise. We also thank Dr. Kazuo Furihata of University of Tokyo for assistance in measuring NMR spectra. This work was partly supported by Grant-in-Aid for Scientific Research on Priority Areas 16073207 from MEXT. ",

year = "2011",

month = nov,

day = "15",

doi = "10.1016/j.bmc.2011.06.052",

language = "English",

volume = "19",

pages = "6594--6598",

journal = "Bioorganic and Medicinal Chemistry",

issn = "0968-0896",

publisher = "Elsevier Limited",

number = "22",

}

TY - JOUR

T1 - Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata

AU - Murayama, Shuhei

AU - Imae, Yasufumi

AU - Takada, Kentaro

AU - Kikuchi, Jo

AU - Nakao, Yoichi

AU - Van Soest, Rob W.M.

AU - Okada, Shigeru

AU - Matsunaga, Shigeki

N1 - Funding Information: We thank the officers and crew of T/S Toyoshio-maru of Hiroshima University for their assistance in collecting the sponge. We thank Kanji Hori for the arrangement of the cruise. We also thank Dr. Kazuo Furihata of University of Tokyo for assistance in measuring NMR spectra. This work was partly supported by Grant-in-Aid for Scientific Research on Priority Areas 16073207 from MEXT.

PY - 2011/11/15

Y1 - 2011/11/15

N2 - Two dimeric steroid derivatives, shishicrellastatin A (1) and B (2), have been isolated as cathepsin B inhibitors from the marine sponge Crella (Yvesia) spinulata. Their structures were determined by interpretation of spectroscopic data. Shishicrellastatins inhibit cathepsin B with an IC 50 value of 8 μg/mL each.

AB - Two dimeric steroid derivatives, shishicrellastatin A (1) and B (2), have been isolated as cathepsin B inhibitors from the marine sponge Crella (Yvesia) spinulata. Their structures were determined by interpretation of spectroscopic data. Shishicrellastatins inhibit cathepsin B with an IC 50 value of 8 μg/mL each.

KW - Cathepsin B

KW - Crellastatin

KW - Dimeric

KW - Sponge

KW - Steroid

KW - Structure elucidation

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U2 - 10.1016/j.bmc.2011.06.052

DO - 10.1016/j.bmc.2011.06.052

M3 - Article

C2 - 21764589

AN - SCOPUS:80055015460

SN - 0968-0896

VL - 19

SP - 6594

EP - 6598

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 22

ER -

Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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