Simple action potential measurement of cardiac cell sheet utilizing electronic sheet

Takashi Ohya, Kazuki Nakazono, Tetsutaro Kikuchi, Daisuke Sasaki, Katsuhisa Sakaguchi, Tatsuya Shimizu, Kenjiro Fukuda, Takao Someya, Shinjiro Umezu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


In this study, a device for measuring the action potential of cardiac cell sheets was developed. The action potential was measured using a device comprising a 2-µm-thick parylene film with a silver electrode printed on it, which was referred to as the “electronic sheet.” The thin parylene film exhibits high biocompatibility and flexibility. Therefore, it demonstrates promise for biomedical microelectromechanical system applications. In this study, a cell sheet was used because the interest it had garnered in regenerative medicine for creating cardiac tissue in vitro similar to that in vivo. A high-efficiency drug development system can be realized by combining cell sheet technology and fabricating a flexible electronic sheet. The action potential of a cardiac cell sheet from a rat was measured using the as-developed flexible electronic sheet.

Original languageEnglish
Pages (from-to)321-327
Number of pages7
JournalArtificial Life and Robotics
Issue number3
Publication statusPublished - 2018 Sept 1


  • Action potential
  • Cell sheet
  • Flexible electronics
  • Printed electronics
  • Regenerative medicine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Artificial Intelligence


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