Simultaneous imaging of magnetic resonance imaging and positron emission tomography by means of MRI-compatible optic fiber-based PET: A validation study in ex vivo rat brain

Masao Imaizumi; Seiichi Yamamoto; Makoto Kawakami; Masaaki Aoki; Eiji Sugiyama; Yasukazu Kanai; Eku Shimosegawa; Jun Hatazawa

doi:10.1007/s11604-009-0328-1

Simultaneous imaging of magnetic resonance imaging and positron emission tomography by means of MRI-compatible optic fiber-based PET: A validation study in ex vivo rat brain

Masao Imaizumi^*, Seiichi Yamamoto, Makoto Kawakami, Masaaki Aoki, Eiji Sugiyama, Yasukazu Kanai, Eku Shimosegawa, Jun Hatazawa

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Purpose: We developed a new type of scintillation detector ring for positron emission tomography (PET). In this device the scintillation detectors were connected with 2.6 m length optic fibers to transport scintillation light to a photomultiplier (PMT) located apart from the detector rings. The present study aimed to test the possibility of simultaneous imaging with PET and magnetic resonance imaging (MRI) by means of the present PET device in ex vivo rat brain. Materials and methods: The scintillation detector ring of 4 cm diameter was located in a magnetic field of 0.15 T open MRI. Simultaneous measurements of PET and MRI were performed in ex vivo rat brain after injection of ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) 37 MBq and ¹⁸F-NaF 37 MBq. Simultaneous data acquisition was performed for 10 min for PET and 5 min for T1-weighted MRI. Results: Simultaneous imaging of PET and MRI was possible without noticeable image distortion in the PET and MRI scans. In the fusion images, high uptake of ¹⁸F-FDG was identified in the Harderian glands and striatum. High uptake of ¹⁸F-NaF was found in the skull base and vault. Conclusions: The present study indicated the possibility of simultaneous imaging of PET and MRI by means of optic fiber-based scintillation detectors.

Original language	English
Pages (from-to)	252-256
Number of pages	5
Journal	Japanese Journal of Radiology
Volume	27
Issue number	6
DOIs	https://doi.org/10.1007/s11604-009-0328-1
Publication status	Published - 2009 Jul
Externally published	Yes

Keywords

MRI
Multimodality imaging
Optical fiber
Permanent magnet
PET

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1007/s11604-009-0328-1

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Imaizumi, M., Yamamoto, S., Kawakami, M., Aoki, M., Sugiyama, E., Kanai, Y., Shimosegawa, E., & Hatazawa, J. (2009). Simultaneous imaging of magnetic resonance imaging and positron emission tomography by means of MRI-compatible optic fiber-based PET: A validation study in ex vivo rat brain. Japanese Journal of Radiology, 27(6), 252-256. https://doi.org/10.1007/s11604-009-0328-1

Simultaneous imaging of magnetic resonance imaging and positron emission tomography by means of MRI-compatible optic fiber-based PET: A validation study in ex vivo rat brain. / Imaizumi, Masao; Yamamoto, Seiichi; Kawakami, Makoto et al.
In: Japanese Journal of Radiology, Vol. 27, No. 6, 07.2009, p. 252-256.

Research output: Contribution to journal › Article › peer-review

Imaizumi, M, Yamamoto, S, Kawakami, M, Aoki, M, Sugiyama, E, Kanai, Y, Shimosegawa, E & Hatazawa, J 2009, 'Simultaneous imaging of magnetic resonance imaging and positron emission tomography by means of MRI-compatible optic fiber-based PET: A validation study in ex vivo rat brain', Japanese Journal of Radiology, vol. 27, no. 6, pp. 252-256. https://doi.org/10.1007/s11604-009-0328-1

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abstract = "Purpose: We developed a new type of scintillation detector ring for positron emission tomography (PET). In this device the scintillation detectors were connected with 2.6 m length optic fibers to transport scintillation light to a photomultiplier (PMT) located apart from the detector rings. The present study aimed to test the possibility of simultaneous imaging with PET and magnetic resonance imaging (MRI) by means of the present PET device in ex vivo rat brain. Materials and methods: The scintillation detector ring of 4 cm diameter was located in a magnetic field of 0.15 T open MRI. Simultaneous measurements of PET and MRI were performed in ex vivo rat brain after injection of 18F-fluorodeoxyglucose (18F-FDG) 37 MBq and 18F-NaF 37 MBq. Simultaneous data acquisition was performed for 10 min for PET and 5 min for T1-weighted MRI. Results: Simultaneous imaging of PET and MRI was possible without noticeable image distortion in the PET and MRI scans. In the fusion images, high uptake of 18F-FDG was identified in the Harderian glands and striatum. High uptake of 18F-NaF was found in the skull base and vault. Conclusions: The present study indicated the possibility of simultaneous imaging of PET and MRI by means of optic fiber-based scintillation detectors.",

keywords = "MRI, Multimodality imaging, Optical fiber, Permanent magnet, PET",

author = "Masao Imaizumi and Seiichi Yamamoto and Makoto Kawakami and Masaaki Aoki and Eiji Sugiyama and Yasukazu Kanai and Eku Shimosegawa and Jun Hatazawa",

note = "Funding Information: Acknowledgment. This work was supported by the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovations.",

year = "2009",

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doi = "10.1007/s11604-009-0328-1",

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T1 - Simultaneous imaging of magnetic resonance imaging and positron emission tomography by means of MRI-compatible optic fiber-based PET

T2 - A validation study in ex vivo rat brain

AU - Imaizumi, Masao

AU - Yamamoto, Seiichi

AU - Kawakami, Makoto

AU - Aoki, Masaaki

AU - Sugiyama, Eiji

AU - Kanai, Yasukazu

AU - Shimosegawa, Eku

AU - Hatazawa, Jun

N1 - Funding Information: Acknowledgment. This work was supported by the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovations.

PY - 2009/7

Y1 - 2009/7

N2 - Purpose: We developed a new type of scintillation detector ring for positron emission tomography (PET). In this device the scintillation detectors were connected with 2.6 m length optic fibers to transport scintillation light to a photomultiplier (PMT) located apart from the detector rings. The present study aimed to test the possibility of simultaneous imaging with PET and magnetic resonance imaging (MRI) by means of the present PET device in ex vivo rat brain. Materials and methods: The scintillation detector ring of 4 cm diameter was located in a magnetic field of 0.15 T open MRI. Simultaneous measurements of PET and MRI were performed in ex vivo rat brain after injection of 18F-fluorodeoxyglucose (18F-FDG) 37 MBq and 18F-NaF 37 MBq. Simultaneous data acquisition was performed for 10 min for PET and 5 min for T1-weighted MRI. Results: Simultaneous imaging of PET and MRI was possible without noticeable image distortion in the PET and MRI scans. In the fusion images, high uptake of 18F-FDG was identified in the Harderian glands and striatum. High uptake of 18F-NaF was found in the skull base and vault. Conclusions: The present study indicated the possibility of simultaneous imaging of PET and MRI by means of optic fiber-based scintillation detectors.

AB - Purpose: We developed a new type of scintillation detector ring for positron emission tomography (PET). In this device the scintillation detectors were connected with 2.6 m length optic fibers to transport scintillation light to a photomultiplier (PMT) located apart from the detector rings. The present study aimed to test the possibility of simultaneous imaging with PET and magnetic resonance imaging (MRI) by means of the present PET device in ex vivo rat brain. Materials and methods: The scintillation detector ring of 4 cm diameter was located in a magnetic field of 0.15 T open MRI. Simultaneous measurements of PET and MRI were performed in ex vivo rat brain after injection of 18F-fluorodeoxyglucose (18F-FDG) 37 MBq and 18F-NaF 37 MBq. Simultaneous data acquisition was performed for 10 min for PET and 5 min for T1-weighted MRI. Results: Simultaneous imaging of PET and MRI was possible without noticeable image distortion in the PET and MRI scans. In the fusion images, high uptake of 18F-FDG was identified in the Harderian glands and striatum. High uptake of 18F-NaF was found in the skull base and vault. Conclusions: The present study indicated the possibility of simultaneous imaging of PET and MRI by means of optic fiber-based scintillation detectors.

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KW - Multimodality imaging

KW - Optical fiber

KW - Permanent magnet

KW - PET

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Simultaneous imaging of magnetic resonance imaging and positron emission tomography by means of MRI-compatible optic fiber-based PET: A validation study in ex vivo rat brain

Abstract

Keywords

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