Sodium 1-(12-hydroxy)octadecanyl sulfate, an MMP2 inhibitor, isolated from a tunicate of the family polyclinidae

Masaki Fujita; Yoichi Nakao; Shigeki Matsunaga; Teruaki Nishikawa; Nobuhiro Fusetani

doi:10.1021/np020250o

Sodium 1-(12-hydroxy)octadecanyl sulfate, an MMP2 inhibitor, isolated from a tunicate of the family polyclinidae

Masaki Fujita, Yoichi Nakao, Shigeki Matsunaga, Teruaki Nishikawa, Nobuhiro Fusetani^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Sodium 1-(12-hydroxy)octadecanyl sulfate (1) was isolated from a marine tunicate as a matrix metalloproteinase 2 (MMP2) inhibitor.¹ The structure was elucidated by a combination of spectroscopic and chemical methods. Compound 1 inhibited MMP2 with an IC₅₀ value of 9.0 μg/mL.

Original language	English
Pages (from-to)	1936-1938
Number of pages	3
Journal	Journal of Natural Products
Volume	65
Issue number	12
DOIs	https://doi.org/10.1021/np020250o
Publication status	Published - 2002 Dec 1
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/np020250o

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abstract = "Sodium 1-(12-hydroxy)octadecanyl sulfate (1) was isolated from a marine tunicate as a matrix metalloproteinase 2 (MMP2) inhibitor.1 The structure was elucidated by a combination of spectroscopic and chemical methods. Compound 1 inhibited MMP2 with an IC50 value of 9.0 μg/mL.",

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AU - Fujita, Masaki

AU - Nakao, Yoichi

AU - Matsunaga, Shigeki

AU - Nishikawa, Teruaki

AU - Fusetani, Nobuhiro

PY - 2002/12/1

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N2 - Sodium 1-(12-hydroxy)octadecanyl sulfate (1) was isolated from a marine tunicate as a matrix metalloproteinase 2 (MMP2) inhibitor.1 The structure was elucidated by a combination of spectroscopic and chemical methods. Compound 1 inhibited MMP2 with an IC50 value of 9.0 μg/mL.

AB - Sodium 1-(12-hydroxy)octadecanyl sulfate (1) was isolated from a marine tunicate as a matrix metalloproteinase 2 (MMP2) inhibitor.1 The structure was elucidated by a combination of spectroscopic and chemical methods. Compound 1 inhibited MMP2 with an IC50 value of 9.0 μg/mL.

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DO - 10.1021/np020250o

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Sodium 1-(12-hydroxy)octadecanyl sulfate, an MMP2 inhibitor, isolated from a tunicate of the family polyclinidae

Abstract

ASJC Scopus subject areas

UN SDGs

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