Sonodynamic Therapy Based on Combined Use of Low Dose Administration of Epirubicin-Incorporating Drug Delivery System and Focused Ultrasound

Masanori Maeda; Yoshihiro Muragaki; Jun Okamoto; Shin Yoshizawa; Nobutaka Abe; Hidekazu Nakamoto; Hiroshi Ishii; Kenichi Kawabata; Shinichiro Umemura; Nobuhiro Nishiyama; Kazunori Kataoka; Hiroshi Iseki

doi:10.1016/j.ultrasmedbio.2017.06.003

Sonodynamic Therapy Based on Combined Use of Low Dose Administration of Epirubicin-Incorporating Drug Delivery System and Focused Ultrasound

Masanori Maeda, Yoshihiro Muragaki^*, Jun Okamoto, Shin Yoshizawa, Nobutaka Abe, Hidekazu Nakamoto, Hiroshi Ishii, Kenichi Kawabata, Shinichiro Umemura, Nobuhiro Nishiyama, Kazunori Kataoka, Hiroshi Iseki

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Sonodynamic therapy (SDT) is currently considered as one of the promising minimally invasive treatment options for solid cancers. SDT is based on the combined use of a sonosensitizer drug and high-intensity focused ultrasound (HIFU) to produce cytotoxic reactive oxygen species (ROS) in and around neoplastic cells. Anthracycline drugs, including epirubicin (EPI), have been well known as effective sonosensitizers after interaction with focused ultrasound. Recently a new anticancer drug delivery system (DDS), NC-6300, has been developed that comprises EPI through an acid–labile hydrazone bond. In previous in vivo studies, NC-6300 showed basic drug safety and an excellent concentration property of EPI, and recently has been tested in clinical trials. For realizing minimally invasive cancer treatment, the present study demonstrated the effectiveness and feasibility of DDS-based SDT, which combined a small dose of NC-6300 and low energy of HIFU in mouse models of colon cancer and pancreatic cancer.

Original language	English
Pages (from-to)	2295-2301
Number of pages	7
Journal	Ultrasound in Medicine and Biology
Volume	43
Issue number	10
DOIs	https://doi.org/10.1016/j.ultrasmedbio.2017.06.003
Publication status	Published - 2017 Oct

Keywords

Colon cancer
Drug delivery system (DDS)
Epirubicin
High intensity focused ultrasound (HIFU)
In vivo
Micellar
Pancreatic cancer
Sonodynamic therapy (SDT)

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Biophysics
Acoustics and Ultrasonics

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Maeda, M., Muragaki, Y., Okamoto, J., Yoshizawa, S., Abe, N., Nakamoto, H., Ishii, H., Kawabata, K., Umemura, S., Nishiyama, N., Kataoka, K., & Iseki, H. (2017). Sonodynamic Therapy Based on Combined Use of Low Dose Administration of Epirubicin-Incorporating Drug Delivery System and Focused Ultrasound. Ultrasound in Medicine and Biology, 43(10), 2295-2301. https://doi.org/10.1016/j.ultrasmedbio.2017.06.003

Maeda, M, Muragaki, Y, Okamoto, J, Yoshizawa, S, Abe, N, Nakamoto, H, Ishii, H, Kawabata, K, Umemura, S, Nishiyama, N, Kataoka, K & Iseki, H 2017, 'Sonodynamic Therapy Based on Combined Use of Low Dose Administration of Epirubicin-Incorporating Drug Delivery System and Focused Ultrasound', Ultrasound in Medicine and Biology, vol. 43, no. 10, pp. 2295-2301. https://doi.org/10.1016/j.ultrasmedbio.2017.06.003

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AU - Kawabata, Kenichi

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AU - Nishiyama, Nobuhiro

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Sonodynamic Therapy Based on Combined Use of Low Dose Administration of Epirubicin-Incorporating Drug Delivery System and Focused Ultrasound

Abstract

Keywords

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