Space-time fluid-structure interaction modeling of patient-specific cerebral aneurysms

Tayfun E. Tezduyar*, Kenji Takizawa, Tyler Brummer, Peng R. Chen

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

88 Citations (Scopus)


We provide an extensive overview of the core and special techniques developed earlier by the Team for Advanced Flow Simulation and Modeling (T{black star}AFSM) for space-time fluid-structure interaction (FSI) modeling of patient-specific cerebral aneurysms. The core FSI techniques are the Deforming-Spatial-Domain/Stabilized Space-Time (DSD/SST) formulation and the stabilized space-time FSI (SSTFSI) technique. The special techniques include techniques for calculating an estimated zero-pressure (EZP) arterial geometry, a special mapping technique for specifying the velocity profile at an inflow boundary with non-circular shape, techniques for using variable arterial wall thickness, mesh generation techniques for building layers of refined fluid mechanics mesh near the arterial walls, a recipe for pre-FSI computations that improve the convergence of the FSI computations, the Sequentially-Coupled Arterial FSI (SCAFSI) technique and its multiscale versions, techniques for the projection of fluid-structure interface stresses, calculation of the wall shear stress (WSS) and calculation of the oscillatory shear index (OSI) and arterial-surface extraction and boundary condition techniques. We show how these techniques work with results from earlier computations. We also describe the arterial FSI techniques developed and implemented recently by the T{black star}AFSM and present a sample from a wide set of patient-specific cerebral-aneurysm models we computed recently.

Original languageEnglish
Pages (from-to)1665-1710
Number of pages46
JournalInternational Journal for Numerical Methods in Biomedical Engineering
Issue number11
Publication statusPublished - 2011 Nov


  • Cardiovascular fluid mechanics
  • Cerebral aneurysms
  • Fluid-structure interactions
  • Space-time methods
  • Special techniques

ASJC Scopus subject areas

  • Software
  • Biomedical Engineering
  • Modelling and Simulation
  • Molecular Biology
  • Computational Theory and Mathematics
  • Applied Mathematics


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