Stereoselective construction of aldol adducts having tertiary alcohol at the α position was achieved via a titanium(IV) enolate derived from a lactate derivative with an Evans chiral auxiliary. The stereochemistry at α-tertiary alcohol could be controlled by selecting the protective group of the starting lactate.
|Number of pages||4|
|Publication status||Published - 2001 Jul 30|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry