Abstract
Stereoselective acylation of the E,E-vinylketene silyl N,O-acetal possessing a chiral auxiliary has been achieved by using acid anhydrides and SnCl4. Acid anhydrides having alkyl chains gave the adducts in excellent stereoselectivity. The formal synthesis of khafrefungin has been accomplished by the methodology.
Original language | English |
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Pages (from-to) | 4106-4109 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 16 |
Issue number | 16 |
DOIs | |
Publication status | Published - 2014 Aug 15 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry