Stereoselective total synthesis of nemorosone

Masahiro Uwamori, Aya Saito, Masahisa Nakada*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)


The highly stereoselective total synthesis of nemorosone via a new approach to the bicyclo[3.3.1]nonane-2,4,9-trione core which features intramolecular cyclopropanation of an α-diazo ketone, stereoselective alkylation at the C8 position, and regioselective ring-opening of cyclopropane is described. The total synthesis of nemorosone includes chemo- and stereoselective hydrogenation directed by the internal alkene.

Original languageEnglish
Pages (from-to)5098-5107
Number of pages10
JournalJournal of Organic Chemistry
Issue number11
Publication statusPublished - 2012 Jun 1

ASJC Scopus subject areas

  • Organic Chemistry


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