Stimulation of nerve growth factor synthesis and secretion by fellutamide A in vitro.

K. Yamaguchi*, T. Tsuji, S. Wakuri, Kazunaga Yazawa, K. Kondo, H. Shigemori, J. Kobayashi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


Fellutamide A, a tripeptide derivative from Penicillium fellutanum was found to be a potent enhancer of nerve growth factor (NGF) synthesis and secretion in vitro. This compound enhanced production of NGF in L-M cells, rat brain cells, and rat glial cells. The mode of action of this compound was suggested to be different from that of a known NGF inducer, epinephrine, as inducing activities of fellutamide A and epinephrine were additive when they were admixed at the concentration which gave saturation in its respective activity. Furthermore, fellutamide A but not epinephrine induced production of NGF in the rat brain cells. NGF-inducing activity of several tripeptides and other compounds related to fellutamide A was examined.

Original languageEnglish
Pages (from-to)195-199
Number of pages5
JournalBioscience, Biotechnology, and Biochemistry
Issue number2
Publication statusPublished - 1993 Feb
Externally publishedYes

ASJC Scopus subject areas

  • Food Science
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biotechnology
  • Chemistry (miscellaneous)
  • Applied Microbiology and Biotechnology


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