Stimulation of the 5-HT(1A) receptor selectively suppresses NMDA receptor-mediated synaptic excitation in the rat visual cortex

Yoshikuni Edagawa; Hiroshi Saito; Kazuho Abe

doi:10.1016/S0006-8993(99)01300-1

Stimulation of the 5-HT(1A) receptor selectively suppresses NMDA receptor-mediated synaptic excitation in the rat visual cortex

Yoshikuni Edagawa, Hiroshi Saito, Kazuho Abe^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

We have previously found that stimulation of serotonin 5-HT(1A) receptors inhibits the induction of long-term potentiation (LTP) in the rat visual cortex. In the present study, the selective 5-HT(1A) receptor agonist 8-hydroxy-2-(N,N-dipropylamino)tetralin (8-OH-DPAT) significantly reduced N- methyl-D-aspartate (NMDA) receptor-mediated synaptic responses recorded in Mg²⁺-free medium in rat visual cortical slices. In addition, there was good correlation between the inhibitory effects of 8-OH-DPAT on NMDA responses and LTP. These results suggest that 5-HT(1A) receptor stimulation inhibits the induction of LTP by suppressing NMDA receptor-mediated synaptic excitation in the rat visual cortex.

Original language	English
Pages (from-to)	225-228
Number of pages	4
Journal	Brain Research
Volume	827
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(99)01300-1
Publication status	Published - 1999 May 8
Externally published	Yes

Keywords

8-Hydroxy-2-(N,N-dipropylamino)tetralin (8- OH-DPAT)
Long-term potentiation
N-methyl-D-aspartate receptor
Serotonin 5-HT(1A) receptor
Visual cortex

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(99)01300-1

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title = "Stimulation of the 5-HT(1A) receptor selectively suppresses NMDA receptor-mediated synaptic excitation in the rat visual cortex",

abstract = "We have previously found that stimulation of serotonin 5-HT(1A) receptors inhibits the induction of long-term potentiation (LTP) in the rat visual cortex. In the present study, the selective 5-HT(1A) receptor agonist 8-hydroxy-2-(N,N-dipropylamino)tetralin (8-OH-DPAT) significantly reduced N- methyl-D-aspartate (NMDA) receptor-mediated synaptic responses recorded in Mg2+-free medium in rat visual cortical slices. In addition, there was good correlation between the inhibitory effects of 8-OH-DPAT on NMDA responses and LTP. These results suggest that 5-HT(1A) receptor stimulation inhibits the induction of LTP by suppressing NMDA receptor-mediated synaptic excitation in the rat visual cortex.",

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AU - Edagawa, Yoshikuni

AU - Saito, Hiroshi

AU - Abe, Kazuho

PY - 1999/5/8

Y1 - 1999/5/8

N2 - We have previously found that stimulation of serotonin 5-HT(1A) receptors inhibits the induction of long-term potentiation (LTP) in the rat visual cortex. In the present study, the selective 5-HT(1A) receptor agonist 8-hydroxy-2-(N,N-dipropylamino)tetralin (8-OH-DPAT) significantly reduced N- methyl-D-aspartate (NMDA) receptor-mediated synaptic responses recorded in Mg2+-free medium in rat visual cortical slices. In addition, there was good correlation between the inhibitory effects of 8-OH-DPAT on NMDA responses and LTP. These results suggest that 5-HT(1A) receptor stimulation inhibits the induction of LTP by suppressing NMDA receptor-mediated synaptic excitation in the rat visual cortex.

AB - We have previously found that stimulation of serotonin 5-HT(1A) receptors inhibits the induction of long-term potentiation (LTP) in the rat visual cortex. In the present study, the selective 5-HT(1A) receptor agonist 8-hydroxy-2-(N,N-dipropylamino)tetralin (8-OH-DPAT) significantly reduced N- methyl-D-aspartate (NMDA) receptor-mediated synaptic responses recorded in Mg2+-free medium in rat visual cortical slices. In addition, there was good correlation between the inhibitory effects of 8-OH-DPAT on NMDA responses and LTP. These results suggest that 5-HT(1A) receptor stimulation inhibits the induction of LTP by suppressing NMDA receptor-mediated synaptic excitation in the rat visual cortex.

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KW - Long-term potentiation

KW - N-methyl-D-aspartate receptor

KW - Serotonin 5-HT(1A) receptor

KW - Visual cortex

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JF - Brain Research

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Stimulation of the 5-HT(1A) receptor selectively suppresses NMDA receptor-mediated synaptic excitation in the rat visual cortex

Abstract

Keywords

ASJC Scopus subject areas

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