TY - JOUR
T1 - Strong inverse correlation between serum TPO level and platelet count in essential thrombocythemia
AU - Tomita, Naoto
AU - Motomura, Shigeki
AU - Sakai, Rika
AU - Fujimaki, Katsumichi
AU - Tanabe, Juichi
AU - Fukawa, Hitoshi
AU - Harano, Hiroshi
AU - Kanamori, Heiwa
AU - Ogawa, Kouji
AU - Mohri, Hiroshi
AU - Maruta, Atsuo
AU - Kodama, Fumio
AU - Ishigatsubo, Yoshiaki
AU - Tahara, Tomoyuki
AU - Kato, Takashi
PY - 2000
Y1 - 2000
N2 - Serum thrombopoietin (TPO) levels in 50 essential thrombocythemia (ET) patients were measured using a highly sensitive sandwich ELISA. In nine cases, TPO levels were measured at two points with different platelet counts. ET patients showed significantly higher serum TPO levels (n = 59, 2.70 ± 2.74 fmol/mL, P < 0.0001) than those of normal individuals (n = 29, 0.83 ± 0.36 fmol/mL). Twenty-three previously untreated ET patients also showed significantly higher serum TPO levels (1.33 ± 0.75 fmol/mL, P = 0.0066) than normal individuals. Extremely high serum TPO levels (5.46 ± 3.68 fmol/mL) were observed in ET patients with normal platelet counts. Furthermore, a strong inverse correlation was found between serum TPO levels and platelet counts in ET patients (R = -0.729, P < 0.0001). This inverse correlation also held for each of nine cases with two-point TPO measurements. In the clinical course of ET, megakaryocyte mass may parallel the platelet mass before and after chemotherapy. Although it is unknown whether overproduction of TPO exists or not in ET, total platelet and megakaryocyte mass, i.e., the total number of c-Mpl, may play a role to regulate serum TPO levels. (C) 2000 Wiley-Liss, Inc.
AB - Serum thrombopoietin (TPO) levels in 50 essential thrombocythemia (ET) patients were measured using a highly sensitive sandwich ELISA. In nine cases, TPO levels were measured at two points with different platelet counts. ET patients showed significantly higher serum TPO levels (n = 59, 2.70 ± 2.74 fmol/mL, P < 0.0001) than those of normal individuals (n = 29, 0.83 ± 0.36 fmol/mL). Twenty-three previously untreated ET patients also showed significantly higher serum TPO levels (1.33 ± 0.75 fmol/mL, P = 0.0066) than normal individuals. Extremely high serum TPO levels (5.46 ± 3.68 fmol/mL) were observed in ET patients with normal platelet counts. Furthermore, a strong inverse correlation was found between serum TPO levels and platelet counts in ET patients (R = -0.729, P < 0.0001). This inverse correlation also held for each of nine cases with two-point TPO measurements. In the clinical course of ET, megakaryocyte mass may parallel the platelet mass before and after chemotherapy. Although it is unknown whether overproduction of TPO exists or not in ET, total platelet and megakaryocyte mass, i.e., the total number of c-Mpl, may play a role to regulate serum TPO levels. (C) 2000 Wiley-Liss, Inc.
KW - Essential thrombocythemia
KW - Platelet
KW - Thrombopoietin
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U2 - 10.1002/(sici)1096-8652(200003)63:3<131::aid-ajh4>3.0.co;2-%23
DO - 10.1002/(sici)1096-8652(200003)63:3<131::aid-ajh4>3.0.co;2-%23
M3 - Article
C2 - 10679802
AN - SCOPUS:0034001439
SN - 0361-8609
VL - 63
SP - 131
EP - 135
JO - American Journal of Hematology
JF - American Journal of Hematology
IS - 3
ER -