Strong inverse correlation between serum TPO level and platelet count in essential thrombocythemia

Naoto Tomita*, Shigeki Motomura, Rika Sakai, Katsumichi Fujimaki, Juichi Tanabe, Hitoshi Fukawa, Hiroshi Harano, Heiwa Kanamori, Kouji Ogawa, Hiroshi Mohri, Atsuo Maruta, Fumio Kodama, Yoshiaki Ishigatsubo, Tomoyuki Tahara, Takashi Kato

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Serum thrombopoietin (TPO) levels in 50 essential thrombocythemia (ET) patients were measured using a highly sensitive sandwich ELISA. In nine cases, TPO levels were measured at two points with different platelet counts. ET patients showed significantly higher serum TPO levels (n = 59, 2.70 ± 2.74 fmol/mL, P < 0.0001) than those of normal individuals (n = 29, 0.83 ± 0.36 fmol/mL). Twenty-three previously untreated ET patients also showed significantly higher serum TPO levels (1.33 ± 0.75 fmol/mL, P = 0.0066) than normal individuals. Extremely high serum TPO levels (5.46 ± 3.68 fmol/mL) were observed in ET patients with normal platelet counts. Furthermore, a strong inverse correlation was found between serum TPO levels and platelet counts in ET patients (R = -0.729, P < 0.0001). This inverse correlation also held for each of nine cases with two-point TPO measurements. In the clinical course of ET, megakaryocyte mass may parallel the platelet mass before and after chemotherapy. Although it is unknown whether overproduction of TPO exists or not in ET, total platelet and megakaryocyte mass, i.e., the total number of c-Mpl, may play a role to regulate serum TPO levels. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalAmerican Journal of Hematology
Issue number3
Publication statusPublished - 2000
Externally publishedYes


  • Essential thrombocythemia
  • Platelet
  • Thrombopoietin

ASJC Scopus subject areas

  • Hematology


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