Structure and sequence of the mouse V1a and V1b vasopressin receptor genes

Shintaro Kikuchi; Akito Tanoue; Nobuhito Goda; Nobutake Matsuo; Gozoh Tsujimoto

doi:10.1254/jjp.81.388

Structure and sequence of the mouse V1a and V1b vasopressin receptor genes

Shintaro Kikuchi, Akito Tanoue, Nobuhito Goda, Nobutake Matsuo, Gozoh Tsujimoto^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The structural organization and 5'-flanking region of the mouse V1a and V1b vasopressin receptor genes were determined. The mouse V1a receptor gene was located within an 8-kb XbaI fragment, and the mouse V1b receptor gene was located within a 14-kb EcoRV fragment. Both genes were comprised of two coding exons that were separated by a 2.3-kb and a 8.0-kb intron, respectively, located before the respective seventh transmembrane domain of the receptor sequence. The availability of these genes would allow us to study the functional role of V1a and V1b receptors by disrupting the gene in mice.

Original language	English
Pages (from-to)	388-392
Number of pages	5
Journal	Japanese Journal of Pharmacology
Volume	81
Issue number	4
DOIs	https://doi.org/10.1254/jjp.81.388
Publication status	Published - 1999
Externally published	Yes

Keywords

V1a vasopressin receptor gene (mouse)
V1b vasopressin receptor gene (mouse)

ASJC Scopus subject areas

Pharmacology

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10.1254/jjp.81.388

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abstract = "The structural organization and 5'-flanking region of the mouse V1a and V1b vasopressin receptor genes were determined. The mouse V1a receptor gene was located within an 8-kb XbaI fragment, and the mouse V1b receptor gene was located within a 14-kb EcoRV fragment. Both genes were comprised of two coding exons that were separated by a 2.3-kb and a 8.0-kb intron, respectively, located before the respective seventh transmembrane domain of the receptor sequence. The availability of these genes would allow us to study the functional role of V1a and V1b receptors by disrupting the gene in mice.",

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AU - Kikuchi, Shintaro

AU - Tanoue, Akito

AU - Goda, Nobuhito

AU - Matsuo, Nobutake

AU - Tsujimoto, Gozoh

PY - 1999

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AB - The structural organization and 5'-flanking region of the mouse V1a and V1b vasopressin receptor genes were determined. The mouse V1a receptor gene was located within an 8-kb XbaI fragment, and the mouse V1b receptor gene was located within a 14-kb EcoRV fragment. Both genes were comprised of two coding exons that were separated by a 2.3-kb and a 8.0-kb intron, respectively, located before the respective seventh transmembrane domain of the receptor sequence. The availability of these genes would allow us to study the functional role of V1a and V1b receptors by disrupting the gene in mice.

KW - V1a vasopressin receptor gene (mouse)

KW - V1b vasopressin receptor gene (mouse)

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Structure and sequence of the mouse V1a and V1b vasopressin receptor genes

Abstract

Keywords

ASJC Scopus subject areas

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