Sugar-Derived Poly(β-thioester)s as a Biomedical Scaffold

Nicholas G. Moon; Fiorella Mazzini; Allison M. Pekkanen; Emily M. Wilts; Timothy Edward Long

doi:10.1002/macp.201800177

Sugar-Derived Poly(β-thioester)s as a Biomedical Scaffold

Nicholas G. Moon, Fiorella Mazzini, Allison M. Pekkanen, Emily M. Wilts, Timothy Edward Long^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

The monomer isosorbide diacrylate (iSDA) and commercially available dithiols allowed access to a range of biosourced, degradable polymers. Altering the dithiol identity significantly affected the glass transition T_gs of the polymer products; however, polymers did not exhibit T_gs above room temperature. Incorporating the comonomer N,N'-methylene bisacrylamide provided mechanical reinforcement through hydrogen bonding, resulting in soft, pliable materials. Differential scannin calorimetry (DSC) and variable-temperature fourier-transform infrared (FTIR) spectroscopy indicated that increases in mechanical integrity resulted from hydrogen bonding. Dynamic mechanical analysis (DMA) revealed materials that exhibited suitable moduli and service windows at body temperature. Biological evaluation demonstrated favorable cytotoxicity and cell attachment, rendering these materials potential candidates as novel scaffold materials for tissue growth.

Original language	English
Journal	Macromolecular Chemistry and Physics
DOIs	https://doi.org/10.1002/macp.201800177
Publication status	Accepted/In press - 2018 Jan 1
Externally published	Yes

Keywords

Biomaterial
Isosorbide
Poly(β-thioester)
Renewable feedstock
Thiol-michael

ASJC Scopus subject areas

Condensed Matter Physics
Physical and Theoretical Chemistry
Polymers and Plastics
Organic Chemistry
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/macp.201800177

Cite this

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title = "Sugar-Derived Poly(β-thioester)s as a Biomedical Scaffold",

abstract = "The monomer isosorbide diacrylate (iSDA) and commercially available dithiols allowed access to a range of biosourced, degradable polymers. Altering the dithiol identity significantly affected the glass transition Tgs of the polymer products; however, polymers did not exhibit Tgs above room temperature. Incorporating the comonomer N,N'-methylene bisacrylamide provided mechanical reinforcement through hydrogen bonding, resulting in soft, pliable materials. Differential scannin calorimetry (DSC) and variable-temperature fourier-transform infrared (FTIR) spectroscopy indicated that increases in mechanical integrity resulted from hydrogen bonding. Dynamic mechanical analysis (DMA) revealed materials that exhibited suitable moduli and service windows at body temperature. Biological evaluation demonstrated favorable cytotoxicity and cell attachment, rendering these materials potential candidates as novel scaffold materials for tissue growth.",

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doi = "10.1002/macp.201800177",

language = "English",

journal = "Macromolecular Chemistry and Physics",

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AU - Moon, Nicholas G.

AU - Mazzini, Fiorella

AU - Pekkanen, Allison M.

AU - Wilts, Emily M.

AU - Long, Timothy Edward

PY - 2018/1/1

Y1 - 2018/1/1

N2 - The monomer isosorbide diacrylate (iSDA) and commercially available dithiols allowed access to a range of biosourced, degradable polymers. Altering the dithiol identity significantly affected the glass transition Tgs of the polymer products; however, polymers did not exhibit Tgs above room temperature. Incorporating the comonomer N,N'-methylene bisacrylamide provided mechanical reinforcement through hydrogen bonding, resulting in soft, pliable materials. Differential scannin calorimetry (DSC) and variable-temperature fourier-transform infrared (FTIR) spectroscopy indicated that increases in mechanical integrity resulted from hydrogen bonding. Dynamic mechanical analysis (DMA) revealed materials that exhibited suitable moduli and service windows at body temperature. Biological evaluation demonstrated favorable cytotoxicity and cell attachment, rendering these materials potential candidates as novel scaffold materials for tissue growth.

AB - The monomer isosorbide diacrylate (iSDA) and commercially available dithiols allowed access to a range of biosourced, degradable polymers. Altering the dithiol identity significantly affected the glass transition Tgs of the polymer products; however, polymers did not exhibit Tgs above room temperature. Incorporating the comonomer N,N'-methylene bisacrylamide provided mechanical reinforcement through hydrogen bonding, resulting in soft, pliable materials. Differential scannin calorimetry (DSC) and variable-temperature fourier-transform infrared (FTIR) spectroscopy indicated that increases in mechanical integrity resulted from hydrogen bonding. Dynamic mechanical analysis (DMA) revealed materials that exhibited suitable moduli and service windows at body temperature. Biological evaluation demonstrated favorable cytotoxicity and cell attachment, rendering these materials potential candidates as novel scaffold materials for tissue growth.

KW - Biomaterial

KW - Isosorbide

KW - Poly(β-thioester)

KW - Renewable feedstock

KW - Thiol-michael

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Sugar-Derived Poly(β-thioester)s as a Biomedical Scaffold

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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