Sugar-Derived Poly(β-thioester)s as a Biomedical Scaffold

Nicholas G. Moon, Fiorella Mazzini, Allison M. Pekkanen, Emily M. Wilts, Timothy Edward Long*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


The monomer isosorbide diacrylate (iSDA) and commercially available dithiols allowed access to a range of biosourced, degradable polymers. Altering the dithiol identity significantly affected the glass transition Tgs of the polymer products; however, polymers did not exhibit Tgs above room temperature. Incorporating the comonomer N,N'-methylene bisacrylamide provided mechanical reinforcement through hydrogen bonding, resulting in soft, pliable materials. Differential scannin calorimetry (DSC) and variable-temperature fourier-transform infrared (FTIR) spectroscopy indicated that increases in mechanical integrity resulted from hydrogen bonding. Dynamic mechanical analysis (DMA) revealed materials that exhibited suitable moduli and service windows at body temperature. Biological evaluation demonstrated favorable cytotoxicity and cell attachment, rendering these materials potential candidates as novel scaffold materials for tissue growth.

Original languageEnglish
JournalMacromolecular Chemistry and Physics
Publication statusAccepted/In press - 2018 Jan 1
Externally publishedYes


  • Biomaterial
  • Isosorbide
  • Poly(β-thioester)
  • Renewable feedstock
  • Thiol-michael

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry
  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry


Dive into the research topics of 'Sugar-Derived Poly(β-thioester)s as a Biomedical Scaffold'. Together they form a unique fingerprint.

Cite this