Super helix formation of actin filaments in an in vitro motile system

Yuichiro Tanaka; Akihiko Ishijima; Shin'ichi Ishiwata

doi:10.1016/0167-4838(92)90079-S

Super helix formation of actin filaments in an in vitro motile system

Yuichiro Tanaka^*, Akihiko Ishijima, Shin'ichi Ishiwata

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Muscle contraction results from relative sliding of actin and myosin filaments. However, the possibility that actin filaments twist or rotate during sliding has not yet been experimentally investigated. We found that a super helix of an actin filament is formed in an in vitro motile system. This fact suggests that an actin filament twists and rotates due to a torque component of a sliding force generated at cross-bridges.

Original language	English
Pages (from-to)	94-98
Number of pages	5
Journal	Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular
Volume	1159
Issue number	1
DOIs	https://doi.org/10.1016/0167-4838(92)90079-S
Publication status	Published - 1992 Sept 4

Keywords

Actin filament
Muscle contraction
Mutile system
Super helix formation

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology
Structural Biology

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10.1016/0167-4838(92)90079-S

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AU - Ishijima, Akihiko

AU - Ishiwata, Shin'ichi

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N2 - Muscle contraction results from relative sliding of actin and myosin filaments. However, the possibility that actin filaments twist or rotate during sliding has not yet been experimentally investigated. We found that a super helix of an actin filament is formed in an in vitro motile system. This fact suggests that an actin filament twists and rotates due to a torque component of a sliding force generated at cross-bridges.

AB - Muscle contraction results from relative sliding of actin and myosin filaments. However, the possibility that actin filaments twist or rotate during sliding has not yet been experimentally investigated. We found that a super helix of an actin filament is formed in an in vitro motile system. This fact suggests that an actin filament twists and rotates due to a torque component of a sliding force generated at cross-bridges.

KW - Actin filament

KW - Muscle contraction

KW - Mutile system

KW - Super helix formation

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Super helix formation of actin filaments in an in vitro motile system

Abstract

Keywords

ASJC Scopus subject areas

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