Suppressing the formation of osteoclasts using bioactive components of the edible mushroom Leccinum extremiorientale (L. Vass.) singer (Agaricomycetideae)

Jae Hoon Choi; Nobuhiko Ozawa; Kikuko Masuda; Tomoyuki Koyama; Kazunaga Yazawa; Hirokazu Kawagishi

Suppressing the formation of osteoclasts using bioactive components of the edible mushroom Leccinum extremiorientale (L. Vass.) singer (Agaricomycetideae)

Jae Hoon Choi, Nobuhiko Ozawa, Kikuko Masuda, Tomoyuki Koyama, Kazunaga Yazawa, Hirokazu Kawagishi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Osteoporosis is a serious health problem for postmenopausal women and the elderly. We have focused our research on the bioactive substances from mushrooms to help cure osteoporosis by suppressing the formation of osteoclasts. In this study, two sterols were isolated from an edible mushroom Leccinum extremiorientale. The structures of 1 and 2 were identified by spectroscopic analysis. Compounds 1 and 2 showed the ability to suppress the formation of osteoclasts. This is the first report of the isolation of the compounds from the genus Leccinum and of the inhibitory activity of these compounds against the formation of osteoclasts.

Original language	English
Pages (from-to)	401-406
Number of pages	6
Journal	International Journal of Medicinal Mushrooms
Volume	12
Issue number	4
Publication status	Published - 2010
Externally published	Yes

Keywords

Leccinum extremiorientale
Medicinal mushrooms
Osteoclast-formation
Sterol
Suppressing substance

ASJC Scopus subject areas

Applied Microbiology and Biotechnology
Drug Discovery
Pharmacology

Cite this

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abstract = "Osteoporosis is a serious health problem for postmenopausal women and the elderly. We have focused our research on the bioactive substances from mushrooms to help cure osteoporosis by suppressing the formation of osteoclasts. In this study, two sterols were isolated from an edible mushroom Leccinum extremiorientale. The structures of 1 and 2 were identified by spectroscopic analysis. Compounds 1 and 2 showed the ability to suppress the formation of osteoclasts. This is the first report of the isolation of the compounds from the genus Leccinum and of the inhibitory activity of these compounds against the formation of osteoclasts.",

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AU - Choi, Jae Hoon

AU - Ozawa, Nobuhiko

AU - Masuda, Kikuko

AU - Koyama, Tomoyuki

AU - Yazawa, Kazunaga

AU - Kawagishi, Hirokazu

PY - 2010

Y1 - 2010

N2 - Osteoporosis is a serious health problem for postmenopausal women and the elderly. We have focused our research on the bioactive substances from mushrooms to help cure osteoporosis by suppressing the formation of osteoclasts. In this study, two sterols were isolated from an edible mushroom Leccinum extremiorientale. The structures of 1 and 2 were identified by spectroscopic analysis. Compounds 1 and 2 showed the ability to suppress the formation of osteoclasts. This is the first report of the isolation of the compounds from the genus Leccinum and of the inhibitory activity of these compounds against the formation of osteoclasts.

AB - Osteoporosis is a serious health problem for postmenopausal women and the elderly. We have focused our research on the bioactive substances from mushrooms to help cure osteoporosis by suppressing the formation of osteoclasts. In this study, two sterols were isolated from an edible mushroom Leccinum extremiorientale. The structures of 1 and 2 were identified by spectroscopic analysis. Compounds 1 and 2 showed the ability to suppress the formation of osteoclasts. This is the first report of the isolation of the compounds from the genus Leccinum and of the inhibitory activity of these compounds against the formation of osteoclasts.

KW - Leccinum extremiorientale

KW - Medicinal mushrooms

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Suppressing the formation of osteoclasts using bioactive components of the edible mushroom Leccinum extremiorientale (L. Vass.) singer (Agaricomycetideae)

Abstract

Keywords

ASJC Scopus subject areas

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