Surface-modified diamond field-effect transistors for enzyme-immobilized biosensors

Kwang Soup Song; Munenori Degawa; Yusuke Nakamura; Hirofumi Kanazawa; Hitoshi Umezawa; Hiroshi Kawarada

doi:10.1143/jjap.43.l814

Surface-modified diamond field-effect transistors for enzyme-immobilized biosensors

Kwang Soup Song^*, Munenori Degawa, Yusuke Nakamura, Hirofumi Kanazawa, Hitoshi Umezawa, Hiroshi Kawarada

^*Corresponding author for this work

School of Fundamental Science and Engineering

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

The enzyme sensors using electrolyte-solution-gate diamond field effect transistors (SGFETs) have been developed for the first time. The hydrogen-terminated surface channel of the FETs was modified into partially aminated and oxygen-terminated (H-A-O-terminated) with irradiation of ultraviolet in an ammonia environment. The pH response of that is obtained about 50 mV/pH at pH 2-10. The concentration of substrates (urea or glucose) in the electrolyte solution has been detected by the pH change due to the bio-catalyzed effect of enzyme (urease or glucose oxidase), which is immobilized on the channel of SGFETs. The sensitivity of urea and glucose is approximately 30 mV/decade and 20 mV/decade respectively.

Original language	English
Pages (from-to)	L814-L817
Journal	Japanese Journal of Applied Physics, Part 2: Letters
Volume	43
Issue number	6 B
DOIs	https://doi.org/10.1143/jjap.43.l814
Publication status	Published - 2004 Jun 15

Keywords

Diamond SGFETs
Enzyme
Glucose
H-A-O-terminated
Urea

ASJC Scopus subject areas

Engineering(all)
Physics and Astronomy(all)

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10.1143/jjap.43.l814

Cite this

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abstract = "The enzyme sensors using electrolyte-solution-gate diamond field effect transistors (SGFETs) have been developed for the first time. The hydrogen-terminated surface channel of the FETs was modified into partially aminated and oxygen-terminated (H-A-O-terminated) with irradiation of ultraviolet in an ammonia environment. The pH response of that is obtained about 50 mV/pH at pH 2-10. The concentration of substrates (urea or glucose) in the electrolyte solution has been detected by the pH change due to the bio-catalyzed effect of enzyme (urease or glucose oxidase), which is immobilized on the channel of SGFETs. The sensitivity of urea and glucose is approximately 30 mV/decade and 20 mV/decade respectively.",

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AU - Degawa, Munenori

AU - Nakamura, Yusuke

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AU - Umezawa, Hitoshi

AU - Kawarada, Hiroshi

PY - 2004/6/15

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KW - H-A-O-terminated

KW - Urea

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Surface-modified diamond field-effect transistors for enzyme-immobilized biosensors

Abstract

Keywords

ASJC Scopus subject areas

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