Abstract
Liposomes of which the surface was modified with poly(ethylene glycol) (PEG) chains are used to prevent aggregation and fusion and to prolong blood circulation. PEG-lipids were immobilized onto the surface of liposomes by simply adding their aqueous dispersions to the liposome dispersions. However, they dissociated from the liposomes by dilution of the mixed dispersions because they were incorporated into the liposomes in an equilibrium state. For the tight immobilization of the PEG-lipids with the long PEG chain onto the liposome surface, an increased number of alkyl chains is necessary.
| Original language | English |
|---|---|
| Pages | 4939-4940 |
| Number of pages | 2 |
| Publication status | Published - 2005 Dec 1 |
| Event | 54th SPSJ Symposium on Macromolecules - Yamagata, Japan Duration: 2005 Sept 20 → 2005 Sept 22 |
Other
| Other | 54th SPSJ Symposium on Macromolecules |
|---|---|
| Country/Territory | Japan |
| City | Yamagata |
| Period | 05/9/20 → 05/9/22 |
Keywords
- Dissociation
- Dodecapeptide
- Hydrophilic-hydrophobic balance
- Liposome
- Multi alkyl chains
- Poly(ethylene glycol)-lipid
ASJC Scopus subject areas
- Engineering(all)