Syn-selective kobayashi aldol reaction using the E,E-vinylketene silyl N,O -acetal

Yuki Mukaeda, Takuya Kato, Seijiro Hosokawa*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


The Kobayashi aldol reaction is one of the most powerful methods to synthesize the polyketide skeleton and has been applied to the total synthesis of natural products. This methodology has been used to construct anti-aldol products, and only a few precedents on the syn-selective Kobayashi aldol reaction are known. A syn-selective Kobayashi aldol reaction by using the E,E-vinylketene silyl N,O-acetal and an excess amount of Lewis acid is presented.

Original languageEnglish
Pages (from-to)5298-5301
Number of pages4
JournalOrganic Letters
Issue number20
Publication statusPublished - 2012 Oct 19

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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