Synthesis and biological evaluation of molecular probes based on the 9-methylstreptimidone derivative DTCM-glutarimide

Eisuke Ota; Masatoshi Takeiri; Miyuki Tachibana; Yuichi Ishikawa; Kazuo Umezawa; Shigeru Nishiyama

doi:10.1016/j.bmcl.2011.11.045

Synthesis and biological evaluation of molecular probes based on the 9-methylstreptimidone derivative DTCM-glutarimide

Eisuke Ota, Masatoshi Takeiri, Miyuki Tachibana, Yuichi Ishikawa, Kazuo Umezawa, Shigeru Nishiyama^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Molecular probes based on 3-[(dodecylthiocarbonyl)methyl]glutarimide (DTCM-glutarimide) were synthesized and assessed for inhibitory activity against LPS-induced NO production. Among the probes examined, several derivatives exhibited potential for use in determining the target proteins of DTCM-glutarimide.

Original language	English
Pages (from-to)	164-167
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	22
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2011.11.045
Publication status	Published - 2012 Jan 1
Externally published	Yes

Keywords

9-Methylstreptimidone
Molecular probe
NF-κB
Streptomyces sp

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2011.11.045

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title = "Synthesis and biological evaluation of molecular probes based on the 9-methylstreptimidone derivative DTCM-glutarimide",

abstract = "Molecular probes based on 3-[(dodecylthiocarbonyl)methyl]glutarimide (DTCM-glutarimide) were synthesized and assessed for inhibitory activity against LPS-induced NO production. Among the probes examined, several derivatives exhibited potential for use in determining the target proteins of DTCM-glutarimide.",

keywords = "9-Methylstreptimidone, Molecular probe, NF-κB, Streptomyces sp",

author = "Eisuke Ota and Masatoshi Takeiri and Miyuki Tachibana and Yuichi Ishikawa and Kazuo Umezawa and Shigeru Nishiyama",

note = "Funding Information: This work was financially supported in part by a High-Tech Research Center Project for Private Universities : matching fund subsidy from MEXT, 2006–2011, and by the Science Research Promotion Fund from the Promotion and Mutual Aid Corporation for Private School of Japan from MEXT. ",

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T1 - Synthesis and biological evaluation of molecular probes based on the 9-methylstreptimidone derivative DTCM-glutarimide

AU - Ota, Eisuke

AU - Takeiri, Masatoshi

AU - Tachibana, Miyuki

AU - Ishikawa, Yuichi

AU - Umezawa, Kazuo

AU - Nishiyama, Shigeru

N1 - Funding Information: This work was financially supported in part by a High-Tech Research Center Project for Private Universities : matching fund subsidy from MEXT, 2006–2011, and by the Science Research Promotion Fund from the Promotion and Mutual Aid Corporation for Private School of Japan from MEXT.

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Molecular probes based on 3-[(dodecylthiocarbonyl)methyl]glutarimide (DTCM-glutarimide) were synthesized and assessed for inhibitory activity against LPS-induced NO production. Among the probes examined, several derivatives exhibited potential for use in determining the target proteins of DTCM-glutarimide.

AB - Molecular probes based on 3-[(dodecylthiocarbonyl)methyl]glutarimide (DTCM-glutarimide) were synthesized and assessed for inhibitory activity against LPS-induced NO production. Among the probes examined, several derivatives exhibited potential for use in determining the target proteins of DTCM-glutarimide.

KW - 9-Methylstreptimidone

KW - Molecular probe

KW - NF-κB

KW - Streptomyces sp

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

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ER -

Synthesis and biological evaluation of molecular probes based on the 9-methylstreptimidone derivative DTCM-glutarimide

Abstract

Keywords

ASJC Scopus subject areas

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