TY - JOUR
T1 - Synthesis and structure - anti-tumor-promoting activity relationship of monogalactosyl diacylglycerols
AU - Nagatsu, Akito
AU - Watanabe, Miyako
AU - Ikemoto, Kouji
AU - Hashimoto, Masayo
AU - Murakami, Nobutoshi
AU - Sakakibara, Jinsaki
AU - Tokuda, Harukuni
AU - Nishino, Hoyoku
AU - Iwashima, Akio
AU - Yazawa, Kazunaga
PY - 1994/7/7
Y1 - 1994/7/7
N2 - Monogalactosyl diacylglycerols (MGDG, 1a-t) were synthesized utilizing p-methoxybenzyl group for protection of hydroxyl groups at sugar moiety. Inhibitory activity of MGDG (1a-t) and related compounds on Epstein-Barr virus early antigen activation was evaluated as anti-tumor-promoting activity, and MGDG with oleoyl group (1c,h-j,p,s) showed strong activity.
AB - Monogalactosyl diacylglycerols (MGDG, 1a-t) were synthesized utilizing p-methoxybenzyl group for protection of hydroxyl groups at sugar moiety. Inhibitory activity of MGDG (1a-t) and related compounds on Epstein-Barr virus early antigen activation was evaluated as anti-tumor-promoting activity, and MGDG with oleoyl group (1c,h-j,p,s) showed strong activity.
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U2 - 10.1016/S0960-894X(01)80577-1
DO - 10.1016/S0960-894X(01)80577-1
M3 - Article
AN - SCOPUS:0028301588
SN - 0960-894X
VL - 4
SP - 1619
EP - 1622
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 13
ER -