Synthesis and structure formation in dilute aqueous solution of a chitosan-DNA hybrid

Ilyès Safir; Kien Xuan Ngo; Jancy Nixon Abraham; Majid Ghahraman Afshar; Ewa Pavlova; Corinne Nardin

doi:10.1016/j.polymer.2015.09.072

Synthesis and structure formation in dilute aqueous solution of a chitosan-DNA hybrid

Ilyès Safir, Kien Xuan Ngo, Jancy Nixon Abraham, Majid Ghahraman Afshar, Ewa Pavlova, Corinne Nardin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

In the following is described the combination of straight biochemical and organic routes to graft nucleotide sequences to a chitosan backbone. The resulting chitosan-g-ssDNA hybrid self-assembles into submicrometer size structures in dilute aqueous solution as assessed by atomic force and electron microscopy imaging. The hypothesis of self-assembly driven by chemical incompatibility between the amphiphilic chitosan and nucleic acid grafts is supported further by stability of the self-assembly against ionic strength and pH variations.

Original language	English
Pages (from-to)	29-36
Number of pages	8
Journal	Polymer (United Kingdom)
Volume	79
DOIs	https://doi.org/10.1016/j.polymer.2015.09.072
Publication status	Published - 2015 Nov 19
Externally published	Yes

Keywords

Chitosan
DNA
Self-assembly

ASJC Scopus subject areas

Polymers and Plastics
Organic Chemistry

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10.1016/j.polymer.2015.09.072

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title = "Synthesis and structure formation in dilute aqueous solution of a chitosan-DNA hybrid",

abstract = "In the following is described the combination of straight biochemical and organic routes to graft nucleotide sequences to a chitosan backbone. The resulting chitosan-g-ssDNA hybrid self-assembles into submicrometer size structures in dilute aqueous solution as assessed by atomic force and electron microscopy imaging. The hypothesis of self-assembly driven by chemical incompatibility between the amphiphilic chitosan and nucleic acid grafts is supported further by stability of the self-assembly against ionic strength and pH variations.",

keywords = "Chitosan, DNA, Self-assembly",

author = "Ily{\`e}s Safir and Ngo, {Kien Xuan} and {Nixon Abraham}, Jancy and {Ghahraman Afshar}, Majid and Ewa Pavlova and Corinne Nardin",

year = "2015",

month = nov,

day = "19",

doi = "10.1016/j.polymer.2015.09.072",

language = "English",

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journal = "Polymer (United Kingdom)",

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T1 - Synthesis and structure formation in dilute aqueous solution of a chitosan-DNA hybrid

AU - Safir, Ilyès

AU - Ngo, Kien Xuan

AU - Nixon Abraham, Jancy

AU - Ghahraman Afshar, Majid

AU - Pavlova, Ewa

AU - Nardin, Corinne

PY - 2015/11/19

Y1 - 2015/11/19

N2 - In the following is described the combination of straight biochemical and organic routes to graft nucleotide sequences to a chitosan backbone. The resulting chitosan-g-ssDNA hybrid self-assembles into submicrometer size structures in dilute aqueous solution as assessed by atomic force and electron microscopy imaging. The hypothesis of self-assembly driven by chemical incompatibility between the amphiphilic chitosan and nucleic acid grafts is supported further by stability of the self-assembly against ionic strength and pH variations.

AB - In the following is described the combination of straight biochemical and organic routes to graft nucleotide sequences to a chitosan backbone. The resulting chitosan-g-ssDNA hybrid self-assembles into submicrometer size structures in dilute aqueous solution as assessed by atomic force and electron microscopy imaging. The hypothesis of self-assembly driven by chemical incompatibility between the amphiphilic chitosan and nucleic acid grafts is supported further by stability of the self-assembly against ionic strength and pH variations.

KW - Chitosan

KW - DNA

KW - Self-assembly

UR - http://www.scopus.com/inward/record.url?scp=84944317078&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944317078&partnerID=8YFLogxK

U2 - 10.1016/j.polymer.2015.09.072

DO - 10.1016/j.polymer.2015.09.072

M3 - Article

AN - SCOPUS:84944317078

SN - 0032-3861

VL - 79

SP - 29

EP - 36

JO - Polymer (United Kingdom)

JF - Polymer (United Kingdom)

ER -

Synthesis and structure formation in dilute aqueous solution of a chitosan-DNA hybrid

Abstract

Keywords

ASJC Scopus subject areas

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