Synthesis, characterization and cytotoxicity evaluation on zinc doped hydroxyapatite in collagen matrix

C. L. Popa, C. M. Bartha, M. Albu, R. Guegan, M. Motelica-Heino, M. C. Chifiriuc, C. Bleotu, M. L. Badea, S. Antohe*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


The goal of this study was to obtain at low temperature a functional nano-composite with characteristics similar to the natural bone by using a cost effective method. The structure and morphology of collagen coated zinc doped hydroxyapatite bio-composites (Zn:HAp-CBc) were examined by X-Ray diffraction (XRD) and Scanning Electron Microscopy (SEM). XRD analysis revealed that the unique hexagonal Ca10(PO4)6(OH)2 in P63m space group was observed in the obtained nanocomposites Zn:HAp-CBc. The cytotoxicity of the Zn:HAp-CBc was studied on HeLa cell lines. Cell cycle distribution after treatment was examined by flow cytometry analysis. Our preliminary in vitro studies revealed that the obtained composites based on Zn doped HAp embedded in collagen matrix have excellent biocompatibility and support their further characterization by in vivo approaches and development as a biomaterial used in bone regeneration.

Original languageEnglish
Pages (from-to)681-691
Number of pages11
JournalDigest Journal of Nanomaterials and Biostructures
Issue number2
Publication statusPublished - 2015
Externally publishedYes


  • Bio-composite
  • Collagen
  • Hydroxyapatite
  • Zinc

ASJC Scopus subject areas

  • Structural Biology
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry


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