Abstract
Fluorination of allyl β-keto carboxylates using N-fluoro-2,4,6-pyridinium triflate gave allyl α-fluoro-β-keto carboxylates. Reaction of allyl α-fluoro-β-keto carboxylates with formic acid in the presence of palladium-phosphine catalyst gave α-fluoro ketones. When the palladium-catalyzed reaction was carried out without formic acid, the decarboxylation-allylation took place to give α-fluoro-allylketones. Decarboxylation-dehydrogenation to afford α-fluoro-α,β-unsaturated ketones was carried out with palladium catalysts in acetonitrile.
| Original language | English |
|---|---|
| Pages (from-to) | 487-495 |
| Number of pages | 9 |
| Journal | Tetrahedron |
| Volume | 50 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1991 |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery