Synthesis of albumin/DCP nano-composite particles

Hajime Ohsawa; Atsuo Ito; Yu Sogo; Atsushi Yamazaki; Tadao Ohno

doi:10.4028/0-87849-422-7.239

Synthesis of albumin/DCP nano-composite particles

Hajime Ohsawa^*, Atsuo Ito, Yu Sogo, Atsushi Yamazaki, Tadao Ohno

^*Corresponding author for this work

School of Creative Science and Engineering

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Highly disgregated dicalcium phosphate anhydrate (DCP) nanoparticles 240-367 nm in diameter were synthesized by a reaction between calcium carbonate and phosphoric acid. When the DCP nanoparticles were immersed in a supersaturated calcium phosphate solution containing bovine serum albumin (BSA) and ethanol, BSA/DCP nano-composite particles were synthesized through the coprecipitation of BSA on the DCP nanoparticles. BSA was firmly immobilized on the BSA/DCP nano-composite particles. The results of this study suggest that DCP nanoparticles appear to be useful as a drug delivery vehicle.

Original language	English
Pages (from-to)	239-242
Number of pages	4
Journal	Key Engineering Materials
Volume	330-332 I
DOIs	https://doi.org/10.4028/0-87849-422-7.239
Publication status	Published - 2007 Jan 1

Keywords

Bovine serum albumin
Coprecipitation
Dicalcium phosphate an hydrate
Drug delivery vehicle
Nano particles

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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title = "Synthesis of albumin/DCP nano-composite particles",

abstract = "Highly disgregated dicalcium phosphate anhydrate (DCP) nanoparticles 240-367 nm in diameter were synthesized by a reaction between calcium carbonate and phosphoric acid. When the DCP nanoparticles were immersed in a supersaturated calcium phosphate solution containing bovine serum albumin (BSA) and ethanol, BSA/DCP nano-composite particles were synthesized through the coprecipitation of BSA on the DCP nanoparticles. BSA was firmly immobilized on the BSA/DCP nano-composite particles. The results of this study suggest that DCP nanoparticles appear to be useful as a drug delivery vehicle.",

keywords = "Bovine serum albumin, Coprecipitation, Dicalcium phosphate an hydrate, Drug delivery vehicle, Nano particles",

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doi = "10.4028/0-87849-422-7.239",

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T1 - Synthesis of albumin/DCP nano-composite particles

AU - Ohsawa, Hajime

AU - Ito, Atsuo

AU - Sogo, Yu

AU - Yamazaki, Atsushi

AU - Ohno, Tadao

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Highly disgregated dicalcium phosphate anhydrate (DCP) nanoparticles 240-367 nm in diameter were synthesized by a reaction between calcium carbonate and phosphoric acid. When the DCP nanoparticles were immersed in a supersaturated calcium phosphate solution containing bovine serum albumin (BSA) and ethanol, BSA/DCP nano-composite particles were synthesized through the coprecipitation of BSA on the DCP nanoparticles. BSA was firmly immobilized on the BSA/DCP nano-composite particles. The results of this study suggest that DCP nanoparticles appear to be useful as a drug delivery vehicle.

AB - Highly disgregated dicalcium phosphate anhydrate (DCP) nanoparticles 240-367 nm in diameter were synthesized by a reaction between calcium carbonate and phosphoric acid. When the DCP nanoparticles were immersed in a supersaturated calcium phosphate solution containing bovine serum albumin (BSA) and ethanol, BSA/DCP nano-composite particles were synthesized through the coprecipitation of BSA on the DCP nanoparticles. BSA was firmly immobilized on the BSA/DCP nano-composite particles. The results of this study suggest that DCP nanoparticles appear to be useful as a drug delivery vehicle.

KW - Bovine serum albumin

KW - Coprecipitation

KW - Dicalcium phosphate an hydrate

KW - Drug delivery vehicle

KW - Nano particles

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JO - Key Engineering Materials

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Synthesis of albumin/DCP nano-composite particles

Abstract

Keywords

ASJC Scopus subject areas

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